SKU: C272  / 
    CAS Number: 482-22-4

    Cryptopleurine

    $207.00 - $725.00

    Cryptopleurine is a phenanthroquinolizidine secondary metabolite from Cryptocarya pleurosperma first reported by de la Lande, Melbourne University, Australia in 1948 and its structure revised in 1954. Cryptopleurine has antifungal activity via inhibition of the 40S ribosomal subunit blocking translocation. Cryptopleurine has antiviral and cytotoxic activity, targeting the NF-​κB pathway.

    Molecular Formula  C24H27NO3
    References

    Butcher K and Lawrence L (1976)  Cryptopleurine - an inhibitor of translocation.  Biochem. 15:4755

    De la Lande IS (1948)  The alkaloids of Cryptocarya pleurosperma. Aust. J. Ex.p Biol. Med. Sci. 26:181

    Gellert E and Riggs NV (1954)  Cryptopleurine: An alkaloid of Cryptocarya pleurosperma. Aust J Chem. 7:113

    Wang Y et al (2018)  Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. Bioorg Med Chem. 26:630