Cryptopleurine is a phenanthroquinolizidine secondary metabolite from Cryptocarya pleurosperma first reported by de la Lande, Melbourne University, Australia in 1948 and its structure revised in 1954. Cryptopleurine has antifungal activity via inhibition of the 40S ribosomal subunit blocking translocation. Cryptopleurine has antiviral and cytotoxic activity, targeting the NF-κB pathway.