Cryptopleurine is a phenanthroquinolizidine secondary metabolite from Cryptocarya pleurosperma first reported by de la Lande, Melbourne University, Australia in 1948 and its structure revised in 1954. Cryptopleurine has antifungal activity via inhibition of the 40S ribosomal subunit blocking translocation. Cryptopleurine has antiviral and cytotoxic activity, targeting the NF-κB pathway.
| Molecular Formula | C24H27NO3 |
| References |
Butcher K and Lawrence L (1976) Cryptopleurine - an inhibitor of translocation. Biochem. 15:4755 De la Lande IS (1948) The alkaloids of Cryptocarya pleurosperma. Aust. J. Ex.p Biol. Med. Sci. 26:181 Gellert E and Riggs NV (1954) Cryptopleurine: An alkaloid of Cryptocarya pleurosperma. Aust J Chem. 7:113 Wang Y et al (2018) Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. Bioorg Med Chem. 26:630 |