Cyclopiazonic acid is a tremorigenic indole produced by several species of Aspergillus and Penicillium. Cyclopiazonic acid is a highly specific inhibitor of calcium ATPase of sarcoplasmic reticulum, altering calcium homeostasis and ATP-dependent calcium transport and resulting in the release of intracellular stored Ca2+ without increasing IP3.
Cyclopiazonic acid is soluble in ethanol, methanol, DMF and DMSO.
Cyclopiazonic acid is soluble in ethanol, methanol, DMF and DMSO.
Mechanism of Action | Cyclopiazonic acid is a highly specific inhibitor of calcium ATPase of sarcoplasmic reticulum, altering calcium homeostasis and ATP-dependent calcium transport and resulting in the release of intracellular stored Ca2+ without increasing IP3. |
Molecular Formula | C20H20N2O3 |
References | The isolation and structure of cyclopiazonic acid, a toxic metabolite of Penicillium cyclopium Westling. Holzapfel C. W. Tetrahedron 1968, 24, 2101. Cyclopiazonic acid and related toxins. Holzapfel C. W. In A. Ciegler, S. Kadis and S. J. Ajl (ed.) Microbial toxins, vol. VI. Academic Press Inc., New York. 1971, 435. Isolation of cyclopiazonic acid, cyclopiazonic acid imine and bissecodehydrocyclopiazonic acid from the cultures of Aspergillus versicolor (Vuill.) Tiraboshi. Ohmono S. et al. J. Agric. Chem.Soc. 1973, 47, 57. The acute toxicity of the mycotoxin cyclopiazonic acid to rats. Purchase I. F. H. Toxicol. Appl. Pharmacol. 1971, 18, 114. Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum. Seidler N. W. et al. J. Biol. Chem. 1989, 264, 17816. |