Daunorubicin HCl is a water soluble anthracycline chemotherapeutic agent produced by Streptomyces coeruleorubidus.
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| Mechanism of Action | Daunorubicin acts as a polymerase inhibitor and demonstrates DNA intercalation activity which effectively inhibits cancer progress. |
| Cancer Applications | Daunorubicin HCl has shown to be useful for treatment of acute myeloid leukemia. |
| Molecular Formula | C27H29NO10 · HCl |
| Solubility | 1mg/mL in H2O: Clear and red or orange solution |
| References | Mizuno, N.S., et al., Binding of daunomycin to DNA and the inhibition of RNA and DNA synthesis. Cancer Res. 35, 1542-1546, (1975) Abstract Tan C, Tasaka H, Yu KP, Murphy ML, Karnofsky DA (March 1967). "Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease. Clinical evaluation with special reference to childhood leukemia". Cancer 20 (3): 333–53 Fornari FA, Randolph JK, Yalowich JC, Ritke MK, Gewirtz DA (April 1994). "Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells". Mol Pharmacol 45 (4): 649–56
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