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Detailed Description
CAS Number: 23541-50-6
Molecular Formula: C27H29NO10 · HCl
Molecular Weight: 563.98
Mechanism of Action: Daunorubicin acts as a polymerase inhibitor and demonstrates DNA intercalation activity which effectively inhibits cancer progress.
Storage Conditions: 2-8°C.
Tariff Code: 2941.90.3000
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Applications
Cancer Applications: Daunorubicin HCl has shown to be useful for treatment of acute myeloid leukemia.
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Specifications
Form: Powder
Appearance: Orange-red crystalline powder
Source: Streptomyces peucetius
Water Content (Karl Fischer): ≤3.0%
pH: 4.5-6.5
Assay: (On Dried Basis): 84.2-103.0%
Heavy Metals: ≤0.001%
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Technical Data
Solubility: 1mg/mL in H2O: Clear and red or orange solution
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References
References:
Mizuno, N.S., et al., Binding of daunomycin to DNA and the inhibition of RNA and DNA synthesis. Cancer Res. 35, 1542-1546, (1975) Abstract
Tan C, Tasaka H, Yu KP, Murphy ML, Karnofsky DA (March 1967). "Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease. Clinical evaluation with special reference to childhood leukemia". Cancer 20 (3): 333–53
Fornari FA, Randolph JK, Yalowich JC, Ritke MK, Gewirtz DA (April 1994). "Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells". Mol Pharmacol 45 (4): 649–56
Daunorubicin HCl is a water soluble anthracycline chemotherapeutic agent produced by Streptomyces coeruleorubidus.
This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.
CAS Number: 23541-50-6
Molecular Formula: C27H29NO10 · HCl
Molecular Weight: 563.98
Mechanism of Action: Daunorubicin acts as a polymerase inhibitor and demonstrates DNA intercalation activity which effectively inhibits cancer progress.
Storage Conditions: 2-8°C.
Tariff Code: 2941.90.3000
Cancer Applications: Daunorubicin HCl has shown to be useful for treatment of acute myeloid leukemia.
Form: Powder
Appearance: Orange-red crystalline powder
Source: Streptomyces peucetius
Water Content (Karl Fischer): ≤3.0%
pH: 4.5-6.5
Assay: (On Dried Basis): 84.2-103.0%
Heavy Metals: ≤0.001%
Solubility: 1mg/mL in H2O: Clear and red or orange solution
References:
Mizuno, N.S., et al., Binding of daunomycin to DNA and the inhibition of RNA and DNA synthesis. Cancer Res. 35, 1542-1546, (1975) Abstract
Tan C, Tasaka H, Yu KP, Murphy ML, Karnofsky DA (March 1967). "Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease. Clinical evaluation with special reference to childhood leukemia". Cancer 20 (3): 333–53
Fornari FA, Randolph JK, Yalowich JC, Ritke MK, Gewirtz DA (April 1994). "Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells". Mol Pharmacol 45 (4): 649–56
