Δ2-Avermectin B1a is an irreversible base degradation product of avermectin found in animal treated with avermectin and in the environment. Δ2-Avermectin B1a is formed by rearrangement of the naturally-occurring Δ3-group to the 2-position. Although less active than the parent, Δ2-avermectin B1a is nonetheless active in the at 1 ppm.
Δ2-Avermectin B1a is soluble in ethanol, methanol, DMF or DMSO.
Δ2-Avermectin B1a is soluble in ethanol, methanol, DMF or DMSO.
| References | Base-catalyzed isomerization of avermectins. Pivnichny J.V. et al. J. Agric. Food Chem. 1988, 36, 826. Direct determination of avermectins in plasma at nanogram levels by High-Performance Liquid Chromatography. Pivnichny J.V. et al. J. Pharm. Sci. 1980, 72, 1447. |
