Delta-2-Avermectin B1a is a natural, irreversible base degradation product produced by selective hydrolysis of the terminal saccharide Avermectin under acidic conditions in animals and in the environment. Delta-2-Avermectin B1a is formed by rearrangement of the naturally-occurring delta-3-group to the 2-position. Although less active than the parent, Delta-2-Avermectin B1a is nonetheless active at 1 ppm. Avermectins are a family of natural macrocyclic lactones produced by the soil actinomycete Streptomyces avermitilis. There are eight different Avermectin natural product compounds: A1a, A1b, A2a, A2b, B1a, B1b, B2a, and B2b based upon the structure of the individual compounds. The B1 fraction has the most effective antiparasitic activity.
Delta-2-Avermectin B1a is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | Avermectins can modulate gamma-aminobutyric acid (GABA) chloride channels in vertebrate neurons. |
| Insect Biology Applications | Electrophysiological findings by injection of E. elegans mRNA into Xenopus laevis oocytes indicated that Avermectins act on glutamate-gated chloride channels in nematodes. |
| References |
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