Epigallocatechin Gallate, the catechin found in green tea (Camellia sinensis), has been reported to have an exhaustive list of promising bioactivity. It has antiparasitic activity against Leishmania, antiviral activity against influenza A and hepatitis B viruses, and antifungal activity against Candida albicans. Epigallocatechin Gallate has has anti-inflammatory effects and can induce apoptosis selectively to transformed cells for potential anticancer activity.
Epigallocatechin Gallate is soluble in water.
| Spectrum | Broad-spectrum activity against Gram-negative and Gram-positive bacteria including methicillin-resistant Staphylococcus aureus. |
| References | Gordon NC and Wareham DW (2010) Antimicrobial activity of the green tea polyphenol (−)-epigallocatechin-3-gallate (EGCG) against clinical isolates of Stenotrophomonas maltophilia. Int. J. Antimicrob. Agents 36(2):129-131 Hirasawa M and Takada K (2004). Multiple effects of green tea catechin on the antifungal activity of antimycotics against Candida albicans. J. Antimicrob. Chemother. 53(2):225-229 Inacio JD, Gervazoni L, Canto-Cavalheiro MM and Almeida-Amaral EE (2014). The Effect of (-)-Epigallocatechin 3-O - Gallate in vitro and in vivo in Leishmania braziliensis: Involvement of reactive oxygen species as a mechanism of action. PLoS Negl. Trop. Dis. 8(8) Steinmann J, Buer J, Pietschmann T and Steinmann E (2013). Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea. Br. J. Pharmacol. 168(5):1059-1073 Wang YC and Bachrach U (2002) The specific anti-cancer activity of green tea (−)-epigallocatechin-3-gallate (EGCG). Amino Acids 22(2):131-143 Zhong Y, Chiou Y, Pan M and Shahidi F (2012) Anti-inflammatory activity of lipophilic epigallocatechin gallate (EGCG) derivatives in LPS-stimulated murine macrophages. Food Chem. 134(2):742-748 |