Hainanmycin Sodium is a polyether antiibiotic derived from Streptomyces padanus var. dangfangeusls from the soil of Hainan Island in China, hence the name. It exerts its anticoccidial effect against many species causing avian coccidiosis. Despite being widely used, few publications are available. It can be used in food safety applications to detect antibacterial residues.
| Mechanism of Action | Hainanmycin Sodium has a monoacid polyether structure. It has anti-insect, anti-bacterial and growth-promoting role. It interferes with the biofilm, competing with coccidia and forming a complex with sodium and potassium. |
| Spectrum | Hainanmycin is against Gram-positive bacteria, some anaerobes, and fungi. It is active against many species that cause coccidiosis in poultry, such as Eimeria tenella and E. necatrix |
| Microbiology Applications | A liquid chromatogrphy-tandem mass spectrometry (LC-MS/MS) method relying on mutiple reaction monitoring (MRM) detection was developed for analyzing Hainanmycin in animal feed. Samples were extracted with ethyl acetate adn purified with liquid-liquid extraction (LLE). The limit of detection (LOD) was 0.36 ug/kg and the limit of quantitation (LOQ) was 2 ug/kg. |
| Molecular Formula | C47H79O15Na |
| References |
Gu MengTian G et al (2018) Efficacy experiment of Hainanmycin premix on Eimeria tenella infection in chicken. China Poultry 40 (9):20-23 Luan Y, Cheng L, Tuer AB and Bao X (2019) Review on research and application of Hainanmycin. Hans J. Agric. Sci 9(10):882-886 Wang ZP, Shen JZ, Linhardt RJ, Jiang H and Cheng LL (2017) Liquid to liquid extraction and liquid chromatography-tandem mass spectrometry determination of Hainanmycin in feed. J. Chromatog. B 1046:98-101 |
