Imipenem is a broad-spectrum β-lactam antibiotic, a carbapenem effective against extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae, a group of pathogenic microbes resistant to many first line β-lactam antibiotics and certain cephalosporins. Imipenem is a broad-spectrum antibiotic targeting a wide range of aerobic and anaerobic Gram-positive and Gram-negative bacteria. Imipenem is commonly used in susceptibility testing. Imipenem is sparingly soluble in water.
We also offer:
- Imipenem mixture w/cilastatin (I005)
| Mechanism of Action | β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like many members of the carbapenem subgroup, imipenem is highly resistant to β-lactamase activity. |
| Spectrum | Imipenem is a broad-spectrum antibiotic targeting a wide range of aerobic and anaerobic Gram-positive and Gram-negative bacteria. Resistance to Imipenem may emerge in Pseudomonas aeruginosa. |
| Microbiology Applications | Imipenem is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Imipenem has also shown high potency against high-resistant superbug strains. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
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| Plant Biology Applications | Imipenem has been shown to be effective against bacteria from the genus Burkholderia, a well described plant pathogen, and was shown to be effective for sour skin (onions), slippery skin (bulbs), and cavity disease (mushrooms)(Sojanova et al, 2007). |
| Molecular Formula | C12H17N3O4S · H2O |
| References |
Benjama A and Charkaoui B (1997) Control of Bacillus contaminating date palm tissue in micropropagation using antibiotics. In: Cassells AC (eds) Pathogen and microbial contamination management in micropropagation. Developments in plant pathology. Vol 12 Springer, Dordrecht. pp 207-211 Berg PH, Voit EO and White RL (1996) A pharmacodynamic model for the action of the antibiotic Imipenem on Pseudomonas aeruginosa populations in vitro. Bltn. Mathcal. Biol. 58(5):923-938 Hellinger WC, Brewer NS (1991) Imipenem. Mayo Clinic Proc. 66(10):1074-1081 Pitout JD, Sanders CC, Sanders WE (1997) Antimicrobial resistance with focus on beta-lactam resistance in Gram-negative bacilli. Am J Med 103:51 |
| MIC | Achromobacter xylosoxidans subsp. denitrificans| 0.25 - 4 || Acinetobacter anitratus| ≤0.008 - 128 || Acinetobacter baumannii| 0.008 - 512 || Acinetobacter calcoaceticus| 0.016 - >8 || Acinetobacter haemolyticus| ≤0.008 - >16 || Acinetobacter junii| ≤0.12 - >8 || Acinetobacter lwoffii| ≤0.008 - >16 || Acinetobacter spp.| 0.008 - >64 || Actinomyces gerencseriae| ≤0.015 - 8 || Actinomyces graevenitzii | ≤0.015 - 0.25 || Actinomyces israelii| ≤0.015 - 8 || Actinomyces meyeri| ≤0.015 - 8 || Actinomyces naeslundii| 0.015 - 8 || Actinomyces neuii| ≤0.015 - 0.25 || Actinomyces odontolyticus| ≤0.015 - 8 || Actinomyces radingae| ≤0.015 - 0.25 || Actinomyces schalii| ≤0.015 - 0.25 || Actinomyces spp.| ≤0.008 - 8 || Actinomyces turicensis| ≤0.015 - 0.25 || Actinomyces viscosus| ≤0.015 - 0.5 || Aerococcus spp.| ≤0.008 - 4 || Aerococcus urinae| ≤0.008 - 4 || Aeromonas caviae| 0.25 - 4 || Aeromonas hydrophila| 0.25 - 16 || Aeromonas spp.| 0.12 - 4 || Agrobacterium radiobacter| 0.06 - 1 || Alcaligenes faecalis| 0.06 - >16 || Alcaligenes odorans| 0.25 - 1 || Anaerococcus prevotii| ≤0.016 - 0.25 || Anaerococcus tetradius | ≤0.016 - 0.03 || Arcanobacterium pyogenes| ≤0.03 - 0.25 || Atopobium parvulum| 0.25|| Bacillus proteus| 4|| Bacillus spp.| ≤0.008 - 4 || Bacillus subtilis| <0.025 || Bacteroides caccae| ≤0.06 - 8 || Bacteroides capillosus | 0.06 - 0.25 || Bacteroides distasonis| 0.03 - 8 || Bacteroides eggerthii| ≤0.125 - 0.5 || Bacteroides fragilis| ≤0.008 - >128 || Bacteroides fragilis gr.| 0.03 - 4 || Bacteroides levii| 0.06 - 0.25 || Bacteroides merdae| ≤0.06 - 4 || Bacteroides ovatus| 0.03 - 16 || Bacteroides splanchnicus | 0.06 - 0.25 || Bacteroides spp.| ≤0.004 - 4 || Bacteroides stercoris| 0.06 - 8 || Bacteroides thetaiotaomicron| 0.03 - >128 || Bacteroides uniformis| 0.03 - 4 || Bacteroides ureolyticus| 0.06 - 0.25 || Bacteroides vulgatus| 0.03 - 16 || Bifidobacterium adolescentis| ≤0.03 - 1 || Bifidobacterium bifidum| ≤0.03 - 0.25 || Bifidobacterium breve| ≤0.03 - 2 || Bifidobacterium catenulatum| ≤0.03 - 0.25 || Bifidobacterium dentium| ≤0.03 - 0.25 || Bifidobacterium longum| ≤0.03 - 8 || Bifidobacterium pseudolongum| 8|| Bifidobacterium spp.| ≤0.008 - 2 || Bilophila wadsworthia| 0.06 - 0.5 || Bordetella bronchiseptica| 0.06 - >16 || Bordetella pertussis | 0.25 - 4 || Branhamella catarrhalis| 0.015 - 4 || Brevibacterium spp.| ≤0.03 - >32 || Brevundimonas vesicularis| 0.06 - >64 || Burkholderia cepacia| 0.06 - 256 || Burkholderia spp.| 16 - >32 || Campylobacter fetus| ≤0.06 - 0.25 || Campylobacter gracilis| 0.06 - 0.5 || Campylobacter jejuni| ≤0.008 - 0.12 || Campylobacter pylori| ≤0.008 - 0.015 || Candida albicans| >25000|| Capnocytophaga ochracea | 0.5|| Chryseobacterium indologenes| ≤0.06 - >64 || Chryseobacterium meningosepticum| 32 - 64 || Citrobacter amalonaticus| 0.006 - >8 || Citrobacter braakii| 0.06 - >8 || Citrobacter diversus| 0.06 - >8 || Citrobacter farmeri| 0.06 - >8 || Citrobacter freundii| 0.03 - 16 || Citrobacter koseri| 0.06 - >8 || Citrobacter spp.| 0.06 - >8 || Clostridium aminovalericum| ≤0.03 - 1 || Clostridium baratii| ≤0.03 - 4 || Clostridium bifermentans| ≤0.015 - 4 || Clostridium butyricum| ≤0.015 - 2 || Clostridium cadaveris| ≤0.015 - 4 || Clostridium clostridioforme| ≤0.03 - 4 || Clostridium cochlearium| ≤0.015 - 2 || Clostridium difficile| ≤0.06 - 64 || Clostridium fallax| ≤0.015 - 2 || Clostridium glycolicum| ≤0.015 - 2 || Clostridium hastiforme| 0.06 - 4 || Clostridium histolyticum | 0.06 - 0.5 || Clostridium innocuum| 0.06 - 4 || Clostridium leptum| ≤0.03 - 1 || Clostridium novyi| ≤0.015 - 2 || Clostridium oroticum| ≤0.015 - 2 || Clostridium paraputrificum| ≤0.015 - 2 || Clostridium perfringens| 0.008 - 1 || Clostridium putrificum| 0.125|| Clostridium ramosum| 0.03 - 4 || Clostridium septicum| ≤0.03 - 1 || Clostridium sordellii| ≤0.03 - 4 || Clostridium sphenoides| ≤0.03 - 1 || Clostridium sporogenes| ≤0.03 - 1 || Clostridium spp.| ≤0.004 - 8 || Clostridium subterminale| ≤0.03 - 1 || Clostridium symbiosum| ≤0.03 - 1 || Clostridium tertium| 0.06 - 4 || Collinsella aerofaciens| ≤0.03 - 0.25 || Comamonas acidovorans| 0.25 - 4 || Comamonas spp.| 0.06 - >16 || Corynebacterium| ≤0.015 - >32 || Corynebacterium accolens| ≤0.015 - 4 || Corynebacterium afermentans| ≤0.008 - >32 || Corynebacterium amycolatum| ≤0.008 - >32 || Corynebacterium aquaticum| ≤0.015 - >32 || Corynebacterium falsenii| ≤0.015 - 4 || Corynebacterium jeikeium| ≤0.008 - >32 || Corynebacterium minutissimum| ≤0.015 - >32 || Corynebacterium pseudodiphtheriticum| ≤0.008 - >32 || Corynebacterium spp.| ≤0.007 - >8 || Corynebacterium striatum| ≤0.008 - >16 || Corynebacterium urealyticum| ≤0.008 - >32 || Corynebacterium xerosis| ≤0.03 - >32 || Dermabacter hominis| ≤0.015 - 4 || Desulfovibrio piger | 0.25|| Eggerthella lenta| 0.5 - 4 || Eggerthella lenta| 8|| Eikenella corrodens| ≤0.12 - 1 || Enterobacter aerogenes| 0.125 - 96 || Enterobacter agglomerans| 0.125 - >16 || Enterobacter amnigenus| ≤0.5 - >8 || Enterobacter asburiae| 0.12 - >16 || Enterobacter cancerogenus| 0.12 - >16 || Enterobacter cancerogenus| 0.5|| Enterobacter cancerogenus| 0.12|| Enterobacter cloacae| 0.06 - 97 || Enterobacter gergoviae| ≤0.5 - >8 || Enterobacter hormaechei| ≤0.5 - >8 || Enterobacter intermedius | 0.12 - >16 || Enterobacter sakazakii| 0.125 - >16 || Enterobacter spp.| ≤0.12 - >16 || Enterobacter taylorae| ≤0.5 - >8 || Enterobacteriaceae| ≤0.06 - >16 || Enterococci| 0.25 - 128 || Enterococcus avium| ≤0.03 - >64 || Enterococcus casseliflavus| 0.03 - >16 || Enterococcus durans| 0.03 - >16 || Enterococcus faecalis| 0.03 - ≥128 || Enterococcus faecium| ≤0.03 - >128 || Enterococcus gallinarum| 0.03 - >16 || Enterococcus hirae| ≤1 - >8 || Enterococcus raffinosus| 0.03 - >16 || Enterococcus spp.| 0.03 - >16 || Escherichia coli| 0.006 - >99 || Eubacterium alactolyticum| ≤0.03 - 0.25 || Eubacterium brachy| ≤0.015 - 0.5 || Eubacterium combesii| ≤0.015 - 0.5 || Eubacterium contortum| ≤0.015 - 0.5 || Eubacterium lentum| ≤0.015 - 4 || Eubacterium limosum| ≤0.015 - 0.5 || Eubacterium moniliforme | ≤0.03 - 0.125 || Eubacterium saburreum| ≤0.015 - 0.5 || Eubacterium spp.| ≤0.016 - 0.5 || Eubacterium tenue| ≤0.015 - 0.5 || Eubacterium timidum| ≤0.015 - 0.5 || Eubacterium yurii| ≤0.015 - 0.5 || Finegoldia magna| ≤0.03 - 0.125 || Flavobacterium breve| 0.06 - >16 || Flavobacterium mengosepticum| 0.06 - >16 || Fusobacteria| ≤0.016 - 1 || Fusobacterium mortiferum| 0.06 - 1.5 || Fusobacterium necrophorum| ≤0.0016 - 4 || Fusobacterium nucleatum| ≤0.016 - 4 || Fusobacterium spp.| ≤0.008 - 4 || Fusobacterium varium| 0.06 - 4 || Gemella morbillorum| ≤0.03 - 0.5 || Gram-Positive Anaerobic Cocci| 0.03 - 0.12 || Haemolytic streptococci| 0.002 - 0.25 || Haemophilus aegyptius| ≤0.008 - 2 || Haemophilus aphrophilus| ≤0.008 - 2 || Haemophilus haemolyticus| ≤0.008 - 2 || Haemophilus influenzae| ≤0.008 - 64 || Haemophilus parahaemolyticus| ≤0.008 - 2 || Haemophilus parainfluenzae| ≤0.008 - 2 || Haemophilus spp.| 0.25 - 4 || Hafnia alvei| 0.06 - >16 || Helicobacter pylori| 0.05|| Klebsiella aerogenes| 0.2|| Klebsiella baumannii| 4|| Klebsiella ornithinolytica| 0.06 - >16 || Klebsiella ozaenae| ≤0.5 - >8 || Klebsiella pneumonia| 0.03 - 6250|| Klebsiella spp.| 0.06 - >8 || Klebsiella terrigena| ≤0.5 - >8 || Lactobacillus acidophilus| ≤0.015 - 8 || Lactobacillus brevis| 0.015 - ≤8 || Lactobacillus casei| ≤0.015 - 16 || Lactobacillus catenaforme| ≤0.015 - 8 || Lactobacillus confusus| ≤0.03 - 8 || Lactobacillus delbrueckii| ≤0.03 - 8 || Lactobacillus fermentans| ≤0.015 - 8 || Lactobacillus fermentum| 0.03|| Lactobacillus fermentum| 0.03|| Lactobacillus gasseri| ≤0.03 - >100 || Lactobacillus jensenii| ≤0.015- 8 || Lactobacillus johnsonii| >100 || Lactobacillus lactis| ≤0.03 - 8 || Lactobacillus leichmannii | ≤0.03 - 1 || Lactobacillus minutus| ≤0.015 - 8 || Lactobacillus oris| ≤0.015 - 8 || Lactobacillus paracasei| >100 || Lactobacillus plantarum| ≤0.015 - 8 || Lactobacillus reuteri| 0.06|| Lactobacillus rhamnosus| ≤0.015 - 8 || Lactobacillus salivarius | 1 - 10|| Lactobacillus spp.| ≤0.008 - 4|| Lactobacillus uli | ≤0.03 - 1|| Legionella pneumophila| ≥0.063|| Leuconostoc spp.| >1000|| Listeria monocytogenes| ≤0.008 - 4|| Micrococcus spp.| ≤0.008 - 4|| Micromonas micros| 0.015 - 2|| Moraxella catarrhalis| ≤0.008 - 1|| Morganella morganii| 0.016 - 16|| Morganella spp.| ≤0.12 - 16|| Mycobacterium avium-intracellulare complex| 2 - 32|| Neisseria meningitidis| 0.03 - 1|| Neisseria meningitidis| 0.03|| Neisseria spp.| 0.004 - 0.25|| Nonsporing gram-positive rods| 0.03 - 1|| Ochrobactrum anthropi| 1 - 2|| Oligella ureolytica| ≤0.06 - >64|| Pandoraea apista| <1 - 4|| Pandoraea pnomenusa| <1 - 2|| Pantoea agglomerans| ≤1 - 2|| Pasteurella multocida| 0.03 - 1|| Pasteurella spp.| 0.06 - >16|| Pemphigus mirabilis| 4|| Pemphigus vulgaris| 4|| Peptococcus spp.| 0.004 - 0.5|| Peptoniphilus asaccharolyticus| ≤0.016 - 1|| Peptoniphilus indolicus| 0.5|| Peptostreptococcus anaerobius| 0.004 - 32|| Peptostreptococcus asaccharolyticus| ≤0.015 - 2|| Peptostreptococcus magnus| ≤0.03 - 32|| Peptostreptococcus micros| ≤0.016 - 2|| Peptostreptococcus prevotii| ≤0.015 - 2|| Peptostreptococcus spp.| ≤0.004 - 32|| Peptostreptococcus tetradius| ≤0.016 - 2|| Plesiomonas shigelloides| 0.25 - 1|| Pneumococci| 0.002 - 0.5|| Porphyromonas asaccharolytica| ≤0.016 - 0.25|| Porphyromonas endodontalis | 0.06 - 0.25|| Porphyromonas gingivalis| ≤0.016 - 0.25|| Porphyromonas levii | ≤0.016|| Porphyromonas spp.| ≤0.016 - 1|| Prevotella bivia| ≤0.016 - 2|| Prevotella buccae| ≤0.016 - 4|| Prevotella corporis | ≤0.016 - 0.125|| Prevotella denticola| ≤0.016 - 0.125|| Prevotella disiens| ≤0.016 - 2|| Prevotella heparinolytica | 0.125|| Prevotella intermedia| ≤0.016 - 4|| Prevotella loescheii| ≤0.016 - 0.25|| Prevotella melaninogenica| ≤0.016 - 0.25|| Prevotella melaninogenicus | 0.06 - 4|| Prevotella nigrescens| ≤0.016 - 0.25|| Prevotella oralis| ≤0.016 - 4 || Prevotella oris| ≤0.016 - 0.5|| Prevotella spp.| ≤0.008 - 4|| Prevotella/Porphyromonas spp.| ≤0.016 - 0.125|| Propionibacterium spp.| ≤0.008 - 0.5|| Propionibacterium acnes | ≤0.008 - 1|| Propionibacterium avidum| ≤0.015 - 0.06|| Propionibacterium granulosum| ≤0.015 - 0.125|| Propionibacterium propionicus| ≤0.015 - 0.06|| Proteus mirabilis| 0.016|| Proteus rettgeri| 0.016 - 16|| Proteus spp.| 0.5 - 8|| Proteus vulgaris| 0.016 - 16|| Providencia alcalifaciens| 41290|| Providencia rettgeri| 0.39 - 32|| Providencia spp.| ≤0.12 - >32|| Providencia stuartii| 0.016 - 16|| Pseudomonas aeruginosa| 0.12 - 64000 μg/ml|| Pseudomonas cepacia| 0.25 - >128|| Pseudomonas fluorescens | 0.12 - >16|| Pseudomonas oryzihabitans| 0.13 - 2|| Pseudomonas paucimobilis| 0.12 - >16|| Pseudomonas putida| 0.12 - >16|| Pseudomonas spp.| 0.06 - >16|| Pseudomonas stutzeri| 0.06 - >16|| Pseudomonas vesicularis| 0.12 - >16|| Pseudoramibacter alactolyticus | ≤0.03 - 0.125|| Ralstonia pickettii | ≤0.06 - 2|| Rothia spp.| <0.015 - 4|| Salmonella agona| ≤0.5 - 2|| Salmonella arizonae| ≤0.5 - 2|| Salmonella bareilly| ≤0.5 - 2|| Salmonella enterica| 0.12 - 2|| Salmonella enteritidis| 0.125 - 2|| Salmonella hadar| ≤0.5 - 2|| Salmonella heidelberg| ≤0.5 - 2|| Salmonella infantis| ≤0.5 - 2|| Salmonella litchfield| ≤0.5 - 2|| Salmonella montevideo| ≤0.5 - 2|| Salmonella muenchen| ≤0.5 - 2|| Salmonella newport| ≤0.5 - 2|| Salmonella panama| ≤0.5 - 2|| Salmonella Paratyphi| ≤0.5 - 2|| Salmonella schwarzengrund| ≤0.5 - 2|| Salmonella spp.| 0.12 - 2|| Salmonella stpaul| ≤0.5 - 2|| Salmonella thompson| ≤0.5 - 2|| Salmonella typhi| 0.12 - 2|| Salmonella virchow| ≤0.5 - 2|| Serratia fonticola| ≤0.12 - >8|| Serratia liquefaciens| 0.06 - >16|| Serratia marcescens| 0.12 - >100|| Serratia odorifera| ≤0.12 - >8|| Serratia plymuthica| ≤0.12 - >8|| Serratia rubidaea| 0.06 - >16|| Serratia spp.| ≤0.12 - 16|| Shewanella putrefaciens| 0.06 - >16|| Shigella boydii| 0.06 - ≤0.5|| Shigella dysenteriae| ≤0.5|| Shigella flexneri| 0.06 - 2|| Shigella sonnei| 0.06 - 2|| Shigella spp.| 0.06 - ≤0.5|| Shingella dysenteriae| 0.125 - 2|| Sphingomonas spp.| 0.5 - >64|| Staphylococcus aureus| 0.004 - 195.31|| Staphylococcus auricularis| ≤0.5 - >8|| Staphylococcus capitis| ≤0.5 - >8|| Staphylococcus caprae| ≤0.5 - >8|| Staphylococcus cohnii| ≤0.5 - >8|| Staphylococcus epidermidis| ≤0.004 - 128|| Staphylococcus haemolyticus| ≤0.007 - >128|| Staphylococcus hominis| ≤0.007 - >128|| Staphylococcus intermedius| ≤0.5 - >8|| Staphylococcus lugdunensis| ≤0.5 - >8|| Staphylococcus mitis| ≤0.007 - 1|| Staphylococcus saccharolyticus| ≤0.03|| Staphylococcus sanguis| 0.007 - ≤0.25|| Staphylococcus saprophyticus| 0.015 - >8|| Staphylococcus sciuri| ≤0.5 - >8|| Staphylococcus simulans| ≤0.007 - >8|| Staphylococcus spp.| ≤0.007 - 256|| Staphylococcus warneri| ≤0.5 - >8|| Stenotrophomonas maltophilia| 4 - 512|| Streptococcus agalactiae| 0.008 - 64|| Streptococcus bovis| ≤0.008 - 2|| Streptococcus constellatus| 0.125|| Streptococcus intermedius| 0.5|| Streptococcus milleri| ≤0.008 - 2|| Streptococcus mutans| ≤0.008 - 2|| Streptococcus pneumoniae| 0.002 - 2|| Streptococcus pyogenes| 0.002 - 0.125|| Streptococcus spp.| 0.002 - 288|| Sutterella wadsworthensis| 0.03 - 16|| Veillonella dispar | 0.06|| Veillonella parvula | ≤0.008 - 4|| Veillonella spp.| 0.015 - 4|| Weeksella virosa | ≤0.06 - 0.13|| Xanthomonas maltophilia| 64 - 128|| Yersinia enterocolitica| 0.06 - 16|| |
