Marcfortine A is an indole alkaloid originally isolated from Penicillin roqueforti. It has nematocidal activity. The marcfortines are structurally related to paraherquamides.
Marcfortine A is soluble in ethanol, methanol, DMF or DMSO but has poor water solubility.
| Mechanism of Action | The marcfortines are thought to act by blocking cholinergic neuromuscular transmission. |
| Insect Biology Applications | Marcfortine A has activity against the gastrointestinal nematode Haemonchus contortus (Zinser et al, 2002). |
| Molecular Formula | C28H35N3O4 |
| Spectrum | Marcfortines have broad-spectrum anthelmintic activity that includes drug-resistant strains of nematodes. |
| References |
Blanchflower SE et al (1993) Further novel metabolites of the paraherquamide family. J. Antibiot. 46:1355 Capon RJ et al (2003) Aspergillicins A-E: Five novel depsipeptides from the marine-derived fungus Aspergillus carneus. Org. Biomol. Chem. 1:1856 Johnson SS (2004) Interrelationships among physicochemical properties, absorption and anthelmintic activities of 2-desoxoparaherquamide and selected analogs. J Vet Pharmacol Ther. 27(3):169-181 PMID 15189303 Kuo MS et al (1996) Biosynthesis of Marcfortine A. J. Antibiot. 49(10):1006-1013 Zinser EW (2002) Anthelmintic paraherquamides are cholinergic antagonists in gastrointestinal nematodes and mammals. J. Vet. Pharmacol. Ther. 25(4):241-250 PMID 12213111 |