Methacycline Hydrochloride is a member of the tetracycline antibiotics and is more active against Gram-negative and Gram-positive bacteria than tetracycline and demethylchlortetracycline.
| Application | Methacycline HCl can be used as a synthetic precursor of doxycycline hyclate. |
| Mechanism of Action | Methacycline inhibits protein synthesis by preventing amino-acyl tRNA from binding to the “A” site in the bacterial ribosome. |
| Spectrum | Metacycline has a broad spectrum of activity and is effective against several clinically significant pathogenic bacteria. |
| Impurity Profile | Oxytetracyline: Not more than 1.0% Doxycycline: Not more than 2.0% Other impurities: Not more than 0.5% Total impurities: Not more than 3.0% |
| Molecular Formula | C22H22N2O8 • HCl |
| References | Hubert, E. G., G. M. Kalmanson, J. Z. Montgomerie, and L. B. Guze. "Activity of Methacycline, Related Tetracyclines, and Other Antibiotics Against Various L-Forms and Their Parent Bacteria In Vitro." Antimicrobial Agents and Chemotherapy 2.4 (1972): 276-80. hopra, Ian, and Marilyn Roberts. "Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance."Microbiology and Molecular Biology Reviews (2001): 232-60.Http://www.ncbi.nlm.nih.gov. Web. 21 Aug. 2012. |
