Methacycline HCl is a member of the tetracycline antibiotics and is more active against Gram-negative and Gram-positive bacteria than tetracycline and demethylchlortetracycline.
|Application||Methacycline HCl can be used as a synthetic precursor of doxycycline hyclate.|
|Mechanism of Action||Methacycline inhibits protein synthesis by preventing amino-acyl tRNA from binding to the “A” site in the bacterial ribosome.|
|Spectrum||Metacycline has a broad spectrum of activity and is effective against several clinically significant pathogenic bacteria.|
|Impurity Profile||Oxytetracyline: Not more than 1.0% |
Doxycycline: Not more than 2.0%
Other impurities: Not more than 0.5%
Total impurities: Not more than 3.0%
|Molecular Formula||C22H22N2O8 • HCl|
|References||Hubert, E. G., G. M. Kalmanson, J. Z. Montgomerie, and L. B. Guze. "Activity of Methacycline, Related Tetracyclines, and Other Antibiotics Against Various L-Forms and Their Parent Bacteria In Vitro." Antimicrobial Agents and Chemotherapy 2.4 (1972): 276-80.|
hopra, Ian, and Marilyn Roberts. "Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance."Microbiology and Molecular Biology Reviews (2001): 232-60.Http://www.ncbi.nlm.nih.gov. Web. 21 Aug. 2012.