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Detailed Description
CAS Number: 51596-10-2
Molecular Formula: C31H44O7
Molecular Weight: 528.7
Mechanism of Action: Like the closely related avermectins, Milbemycins are thought to act by opening glutamate sensitive and GABA-sensitive chloride channels.
Storage Conditions: -20°C
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Applications
Spectrum: Milbemycin A3 has activity against insects including mites, nematodes, worms, ticks, flights, and agricultural pests.
Plant Biology Applications: Milbemectin is used as an agri-chemical for crop protection in soft fruits, citrus fruit, top fruit, aubergines and others to combat mites and leaf miners.
Insect Biology Applications:
Milbemectin is a GABA inhibitor and can act as an agonist of the RDL GABA receptor in Drosophila.
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Specifications
Appearance: White solid
Purity Level: >95% by HPLC
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References
References:
Bi Z et al (2015) Efficacy of four nematicides against the reproduction and development of pinewood nematode, Bursaphelenchus xylophilus. J. Nematol. 47(2):126-132 PMID 26170474
Duke SO (2010) Natural toxins for use in pest management. Toxins (Basel) 2(8):1943-1962 PMID 22069667
Kornis GI (1995) Avermectins and Milbemycins. In: Godfrey CRA, ed. Agrochemicals from natural products. Marcel Dekker. New York, NY pp 215–255
Nakao T, Banba and Hirase K (2015) Comparison between the modes of action of novel meta-diamide and macrycyclic lactone insecticides on the RDL GABA receptor. Pest. Biochem. and Physiol. 120:101-108 PMID 25987227
Okazaki T et al (1983) Milbemycins, a new family of macrolide antibiotics: Producing organism and its mutants J Antibiot. 36:438 PMID 6853372
Takiguchi Y et al (1980) Milbemycins, a new family of macrolide antibiotics: Fermentation, isolation and physico-chemical properties. J Antibiot. 33:1120 PMID 7451362
Takiguchi Y et al (1983) Milbemycins, a new family of macrolide antibiotics. Fermentation, isolation and physico-chemical properties of Milbemycins D, E, F, G, and H. J Antibiot.(Tokyo). 36(5):502-508 PMID 6874568
Milbemycin A3 belongs to the family of Milbemycins, 16-membered macrocyclic lactone antibiotics with a 6,6-membered spiroketal ring system. Milbemycin A3 is a highly selective and potent nematocide and insecticide. Milbemycin A3 is a major member of a group of analogs containing a 25-methyl substituent. Milbemycin A3 is a metabolite derived from fermentation of the soil bacterium Streptomyces hydroscopicus subsp. aureolarcrimosus. Milbemycins are analogs of the avermectins. Other Milbemycins include Milbemycin B through H.
Milbemycin A3 is soluble in ethanol, methanol, DMF and DMSO but has poor water solubility.
We also offer:
- Milbemycin A3 Oxime (M058)
CAS Number: 51596-10-2
Molecular Formula: C31H44O7
Molecular Weight: 528.7
Mechanism of Action: Like the closely related avermectins, Milbemycins are thought to act by opening glutamate sensitive and GABA-sensitive chloride channels.
Storage Conditions: -20°C
Spectrum: Milbemycin A3 has activity against insects including mites, nematodes, worms, ticks, flights, and agricultural pests.
Plant Biology Applications: Milbemectin is used as an agri-chemical for crop protection in soft fruits, citrus fruit, top fruit, aubergines and others to combat mites and leaf miners.
Insect Biology Applications:
Milbemectin is a GABA inhibitor and can act as an agonist of the RDL GABA receptor in Drosophila.
Appearance: White solid
Purity Level: >95% by HPLC
References:
Bi Z et al (2015) Efficacy of four nematicides against the reproduction and development of pinewood nematode, Bursaphelenchus xylophilus. J. Nematol. 47(2):126-132 PMID 26170474
Duke SO (2010) Natural toxins for use in pest management. Toxins (Basel) 2(8):1943-1962 PMID 22069667
Kornis GI (1995) Avermectins and Milbemycins. In: Godfrey CRA, ed. Agrochemicals from natural products. Marcel Dekker. New York, NY pp 215–255
Nakao T, Banba and Hirase K (2015) Comparison between the modes of action of novel meta-diamide and macrycyclic lactone insecticides on the RDL GABA receptor. Pest. Biochem. and Physiol. 120:101-108 PMID 25987227
Okazaki T et al (1983) Milbemycins, a new family of macrolide antibiotics: Producing organism and its mutants J Antibiot. 36:438 PMID 6853372
Takiguchi Y et al (1980) Milbemycins, a new family of macrolide antibiotics: Fermentation, isolation and physico-chemical properties. J Antibiot. 33:1120 PMID 7451362
Takiguchi Y et al (1983) Milbemycins, a new family of macrolide antibiotics. Fermentation, isolation and physico-chemical properties of Milbemycins D, E, F, G, and H. J Antibiot.(Tokyo). 36(5):502-508 PMID 6874568
