SKU: M083  / 
    CAS Number: 22373-78-0

    Monensin Sodium, USP

    $57.00 - $175.50
    Monensin Sodium, USP

    Monensin Sodium, USP is a naturally occurring ionophore, used as a nonhormonal growth promoter and  coccidiostat.  It is a polyether antibiotic used against Gram-negative bacteria and has antiparasitic activity.

    Monensin Sodium is soluble in chloroform, methanol, and other organic solvents and slightly soluble in water.

    This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for questions. 

    Mechanism of Action As an ionophore, Monensin can disrupt the natural ion gradients such as Ca2+, Mg2+, K+ and Na+,  and affect transmembrane ion transport.
    Eukaryotic Cell Culture Applications Liver microsomes were used to study the P-450 isoenzymes involved in the biotransformation of the ionophore Monensin and how it may be affected by chemotherapeutic agents. Results suggest that P-450 3A can play an important role in the oxidative metabolism of Monensin (Nebbia et al, 1999).
    Solubility Soluble in chloroform, methanol, and other organic solvents.  Slightly soluble in water.
    References

    Aowicki D and Huczyński A (2013) Structure and antimicrobial properties of Monensin A and its derivatives: Summary of the achievements. Biomed Res Int. 2013:742149  PMID 23509771

    Agtarap A, Chamberlin JW, Pinkerton M, Steinrauf L. (1967) The structure of Monensic acid, a new biologically active compound. J Am Chem Soc. 89(22):5737-5739  PMID 5622366

    Butaye, P, Devriese LA and Haesebrouck F (2003) Antimicrobial growth promoters used in animal feed: Effects of less well known antibiotics on Gram-positive bacteria. Clin. Microbiol. Rev. 16(2): 175–188

    Griffiths G, Quinn P, Warren G (1983)  Dissection of the Golgi complex. I. Monensin inhibits the transport of viral membrane proteins from medial to trans Golgi cisternae in baby hamster kidney cells infected with Semliki Forest virus. J Cell Biol. 1983 Mar;96(3):835-50.  PMID 6682112

    Lowicki, D and Huczyński A  (2013). Structure and antimicrobial properties of Monensin A and its derivatives: Summary of the achievements. BioMed Res. Intl. 1–14. doi:10.1155/2013/742149

    Nebbia C, Ceppa L, Dacasto M, Carletti M, Nachtmann C (1999)  Oxidative metabolism of Monensin in rat liver microsomes and interactions with tiamulin and other chemotherapeutic agents: Evidence for the involvement of cytochrome P-450 3A subfamily. Drug Metab Dispos. 1999 Sep;27(9):1039-44  PMID 10460804