SKU: M033  / 
    CAS Number: 186826-86-8

    Moxifloxacin Hydrochloride

    NT$6,116.96 - NT$24,323.33

    Moxifloxacin Hydrochloride is a broad-spectrum fourth-generation fluoroquinolone antibiotic that can be used against the bacteria causing respiratory infections. Moxifloxacin Hydrochloride is sparingly soluble in aqueous solution.

    Mechanism of Action Fluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and ultimately cell division is inhibited.

    Moxifloxacin is bactericidal against wild-type and first-step gyrase- and topoisomerase IV-resistant mutants.  The 8-methoxy group on moxifloxacin appeared to significantly lower the propensity for quinolone resistance development (Dalhoff, 2011).
    Spectrum Moxifloxacin is a broad-spectrum antibiotic commonly used Gram-positive and Gram-negative bacteria. It is effective against bacteria that case respiratory infections including S. pneumonia. It is also effective for obligate anaerobes including Bacteriodes, Fusobacterium, Bilophila, and Clostridium.
    Impurity Profile Impurity A| 1-Cyclopropyl-6,8-difluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Moxifloxacin Difluoro Analog|151213-15-9|C20H21F2N3O3|389.40| Impurity B| 1-Cyclopropyl-6,8-dimethoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Moxifloxacin Dimethoxy Analog||C22H27N3O5|413.47| Impurity C| 1-Cyclopropyl-8-ethoxy-6-fluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo [3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Moxifloxacin Ethyl Analog||C22H26FN3O4|415.46| Impurity D| 1-Cyclopropyl-8-fluoro-6-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo [3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Moxifloxacin Isomer|1029364-77-9|C21H24FN3O4|401.43| Impurity E| 1-Cyclopropyl-6-fluoro-8-hydroxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo [3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Moxifloxacin Desmethyl Analog||C20H22FN3O4|387.4| Moxifloxacin Decarboxy Analog| Decarboxy Moxifloxacin;1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline||C20H24FN3O2|357.42| Moxifloxacin Difluoro Hydroxy Impurity| 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinoline carboxylic acid|154093-72-8|C13H9F2NO4|281.21| Moxifloxacin Difluoro Methoxy Impurity| 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid|112811-72-0|C14H11F2NO4|295.24| Moxifloxacin N-Methyl Analog| 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-1-methyl-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid hydrochloride||C22H27ClFN3O4|451.92| Moxifloxacin Trifluoro Ethyl Ester| 1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid ethyl ester|94242-51-0|C15H12F3NO3|311.26| Moxifloxacin Trifluoro Impurity| 1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid|94695-52-0|C13H8F3NO3|283.20| Moxifloxacin Methyl Ester| 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid methyl ester|721970-35-0|C22H26FN3O4|415.46| Moxifloxacin Hydrochloride| 1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride|186826-86-8|C21H25ClFN3O4|437.89|
    Microbiology Applications Moxifloxacin Hydrochloride is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options.  Representative MIC values include:
    • Haemophilus influenzae 0.008 µg/mL – 0.25 µg/mL
    • Streptococcus pneumoniae 0.03 µg/mL - 8 µg/mL
    • For a representative list of Moxifloxacin values, click here.
    Eukaryotic Cell Culture Applications A cell culture model to investigate the safety of Moxifloxacin for intracameral application was investigated in cultured human corneas to review endothelial toxicity.  Moxifloxacin at 10-750 µg/ml was evaluated in endothelial cells, primary human trabecular meshwork cells (TMC), and primary human retinal pigment epithelial (RPE) cells.  Concentrations up to 150 µg/ml had no influence on endothelial cells, TMC, or RPE when exposed for up to 24 hours (MIC90 is 0.25-2.5 µg/ml).(Kernt et al, 2009).
    Molecular Formula C21H24FN3O4 · HCl
    References

    Ackermann G et al (2000)  comparative activity of Moxifloxacin in vitro against obligately anaerobic bacteria.  Eur. J. Clin. Microbiol. Infect. Dis. 19(3):228-232 

    Araujo FG, Slifer TL and Remington JS (2002)  Effect of Moxifloxacin on secretion of cytokines by human monocytes stimulated with lipopolysaccharide. Clin. Microbiol. Infect. 8(1):26-30

    Dalhoff A (2001)  Comparative in vitro and in vivo activity of the C-8 methoxy quinolone moxifloxacin and the C-8 chlorine quinolone BAY y 3118. Clin Infect Dis 32 Suppl 1:S16-22  PMID 11249824

    Dalhoff A, Krasemann C, Wegener S, Tillotson G (2001)  Penicillin-resistant Streptococcus pneumoniae: Review of Moxifloxacin activity. Clin Infect Dis. 32 Suppl 1:S22-9  PMID 11249825

    Kernt M et al (2009)  Intracameral Moxifloxacin: In vitro safety on human ocular cells. Cornia 28(5):553-561

    Wolfson JS  and Hooper DC (1985)  The Fluoroquinolones: Structures, mechanisms of action and resistance, and spectra of activity in vitro. 28:581-86

    MIC Bacillus cereus| 0.078|| Bacteroides caccae| 0.25 - 64|| Bacteroides distasonis| ≤0.06 - 32|| Bacteroides eggerthii| 1 - 64|| Bacteroides fragilis| ≤0.06 - 128|| Bacteroides merdae| 0.064 - 32|| Bacteroides ovatus| 0.064 - 64|| Bacteroides stercoris| 1 - 64|| Bacteroides thetaiotaomicron| 0.06 - 64|| Bacteroides uniformis| ≤0.06 - 128|| Bacteroides vulgatus| 0.06 - 128|| Bifidobacterium adolescentis| 0.064 - 4|| Bifidobacterium sp.| 0.064 - 4|| Brucella melitensis| ≥1|| Burkholderia cepacia| 0.12 - >16|| Campylobacter coli| 0.0125 - 128|| Campylobacter jejuni| 0.0125 - 128|| Capnocytophaga spp.| 0.016 - 0.5|| Chlamydia pneumonia| 0.125 - 1|| Chlamydia trachomatis| 0.031 - 1|| Chlamydophila pneumonia| 0.06 - 0.125|| Citrobacter freundii| 0.03 - 32|| Citrobacter koseri| 0.015 - >8|| Citrobacter spp.| 0.015 - 32|| Clostridium baratii| 0.25 - 2|| Clostridium bifermentans| 0.25 - 2|| Clostridium butyricum| 0.12 - 2|| Clostridium cadaveris| 0.25 - 2|| Clostridium clostridioforme| 0.12 - 2|| Clostridium difficile| ≤0.06 - 128|| Clostridium hastiforme| 0.25 - 2|| Clostridium histolyticum | 0.25 - 2|| Clostridium innocuum| 0.25 - 2|| Clostridium paraputrificum| 0.25 - 2|| Clostridium perfringens| 0.12 - 2|| Clostridium ramosum| 0.12 - 2|| Clostridium sordellii| 0.25 - 2|| Clostridium sporogenes| 0.12 - 2|| Clostridium spp.| 0.12 - 2|| Clostridium tertium| 0.25 - 2|| Enterobacter aerogenes| 0.03 - 64|| Enterobacter cloacae| ≤0.015 - >64|| Enterobacter spp.| 0.015 - 32|| Enterobacteriaceae (fluoroquinolone-resistant)| 4 - >64|| Enterococcus faecalis| 0.016 - >32|| Enterococcus faecium| 0.06 - 64|| Escherichia coli| 0.002 - 128|| Eubacterium lentum| ≥0.5|| Eubacterium spp.| 0.25 - 2|| Finegoldia magna| 0.047 - 64|| Fusobacteria| 0.03 - >8|| Fusobacterium mortiferum| 0.06 - 4|| Fusobacterium necrophorum| 0.03 - 4|| Fusobacterium nucleatum| 0.06 - 4|| Fusobacterium spp.| 0.06 - >16|| Fusobacterium varium| 0.06 - >16|| Gemella morbillorum| 0.016 - 0.5|| Haemophilus influenzae| ≤0.015 - 0.5|| Haemophilus parainfluenzae| 0.016 - 0.5|| Haemophilus spp.| 0.19 - 4|| Helicobacter pylori| 0.008 - >32|| Hemolytic streptococci| 0.032 - 0.5|| Klebsiella oxytoca| 0.03 - 8|| Klebsiella pneumonia| 0.008 - >64||