Mupirocin Calcium is a carboxylic acid bacteriostatic/bactericidal antibiotic produced by Pseudomonas fluorescens. It is used against the bacteria causing impetigo and skin infections. The product can be used for kinetic assays and in susceptibility testing applications.
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Mupirocin is very sparingly soluble in water.
| Mechanism of Action | Mupirocin inhibits protein synthesis by binding to isoleucyl-tRNA synthetase, an enzyme which conjugates the amino acid isoleucine to its corresponding tRNA. |
| Spectrum | Mupirocin is commonly used to target Gram-positive bacteria especially Methicillin resistant Staphylococcus aureus (MRSA). It is also active against fungi. |
| Microbiology Applications | Mupirocin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive Staphylococcus microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
Methicillin resistant Staphylococcus aureus 0.25 µg/mL – 0.39 µg/mL For a representative list of Mupirocin MIC values, click here. |
| Molecular Formula | C56H86CaO16 • 2H2O |
| References |
Parenti MA, Hatfield SM, Leyden JJ (1987) Mupirocin: A topical antibiotic with a unique structure and mechanism of action. Clin. Pharm. 6(10):761-770 PMID 3146455 |
