Mupirocin is a carboxylic acid bacteriostatic/bactericidal antibiotic.
TOKU-E offers three forms of mupirocin: mupirocin (M022), mupirocin lithium salt (M023), and mupirocin calcium . Mupirocin is sparingly soluble in aqueous solution at 26.5 µg/mL. Mupirocin lithium is freely soluble at 10 mg/mL.
| Mechanism of Action | Mupirocin inhibits protein synthesis by binding to isoleucyl-tRNA synthetase, an enzyme which conjugates the amino acid isoleucine to its corresponding tRNA. |
| Spectrum | Mupirocin is commonly used to target gram positive bacteria especially Methicillin resistant Staphylococcus aureus (MRSA). |
| Microbiology Applications | Mupirocin lithium salt is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive Staphylococcus microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include: Methicillin resistant Staphylococcus aureus 0.25 µg/mL – 0.39 µg/mL For a complete list of mupirocin MIC values, click here. |
| Optical Rotation | [α] D -21.0±2.0°, c = 1 in H2O |
| References | Hatfield, S. M., J. J. Leyden, and M. I. Parenti. "Mupirocin: A Topical Antibiotic with a Unique Structure and Mechanism of Action." PubMed (1987): 761-70. Http://www.ncbi.nlm.nih.gov. Web. 5 Aug. 2012. |
| MIC | Enterococcus faecalis| 64 － ?| 101| Enterococcus faecalis (ATCC 29212)| 50 － ?| 1026| Enterococcus faecalis (Korea + 1998)| 51.38 － ?| 1026| Enterococcus faecalis (Korea + 2005)| 76.78 － ?| 1026| Enterococcus faecium (ATCC 6057)| 12.5 － ?| 1026| Enterococcus faecium (Korea + 1998)| 1 － ?| 1026| Escherichia coli (CP78)| 0.2 － ?| 313| Escherichia coli (CP79)| 0.05 － ?| 313| Haemophilus influenzae| ≤0.016 － 0.25| 120| Haemophilus influenzae (Spain 7)| 0.024 － ?| 313| Moraxella catarrhalis| 0.5 － 4| 120| Moraxella catarrhalis (489)| 1.56 － ?| 313| Salmonella typhimurium (F596L)| 64 － 384| 790| Salmonella typhimurium (H594Y)| 32 － 256| 790| Salmonella typhimurium (LT2 + JB124)| 16 － 24| 790| Salmonella typhimurium (LT2 + JB1850)| >1024 － ?| 790| Salmonella typhimurium (LT2 + JB1853)| >1024 － ?| 790| Salmonella typhimurium (LT2 + JB1855)| >1024 － ?| 790| Salmonella typhimurium (LT2 + JB1872)| >1024 － ?| 790| Salmonella typhimurium (W443R)| 16 － 128| 790| Salmonella typhimurium (WV630–631L)| 128 － 192| 790| Staphylococci| 0.06 － 1024| 401| Staphylococci (coagulase-negative + beef isolate + Korea)| >128 － ?| 901| Staphylococci (coagulase-negative + pork isolate + Korea)| >128 － ?| 901| Staphylococcus| ? － ?| 906| Staphylococcus (beef isolate + Korea)| ? － ?| 901| Staphylococcus (chicken isolate + Korea)| ? － ?| 901| Staphylococcus (pork isolate + Korea)| ? － ?| 901| Staphylococcus aureus| ≤4 － >128| 604| Staphylococcus aureus| 0.1 － ?| 313| Staphylococcus aureus (103H + methicillin-resistant)| 0.39 － ?| 734| Staphylococcus aureus (10-420 + initial)| 4096 － ?| 789| Staphylococcus aureus (1079077 + initial)| 0.5 － ?| 789| Staphylococcus aureus (1079077 + methicillin-resistant)| 0.25 － ?| 789| Staphylococcus aureus (1079101 + initial)| 4096 － ?| 789| Staphylococcus aureus (118M + methicillin-resistant)| 0.39 － ?| 734| Staphylococcus aureus (145M + methicillin-resistant)| 0.39 － ?| 734| Staphylococcus aureus (25-670 + initial)| 2048 － ?| 789| Staphylococcus aureus (31-1334 + initial)| 32 － ?| 789| Staphylococcus aureus (5)| 0.06 － ?| 120| Staphylococcus aureus (87-2797 + initial)| 2048 － ?| 789| Staphylococcus aureus (936528 + initial)| 2048 － ?| 789| Staphylococcus aureus (936606 + initial)| 0.12 － ?| 789| Staphylococcus aureus (ATCC 25923)| 0.25 － ?| 401| Staphylococcus aureus (ATCC 29213 + initial)| 0.06 － ?| 789| Staphylococcus aureus (ATCC 29213 + methicillin-susceptible)| 0.12 － ?| 789| Staphylococcus aureus (ATCC 29213)| 0.12 － ?| 120| Staphylococcus aureus (ATCC 29213)| 0.12 － ?| 401| Staphylococcus aureus (ATCC 29213)| 0.25 － ?| 601| Staphylococcus aureus (ATCC 43300 + initial)| 0.06 － ?| 789| Staphylococcus aureus (ATCC 43300 + methicillin-resistant)| 0.12 － ?| 789| Staphylococcus aureus (ATCC 6571)| 0.25 － ?| 401| Staphylococcus aureus (community-acquired + methicillin-resistant)| ≤4 － >128| 604| Staphylococcus aureus (erythromycin-resistant)| ≤2 － >256| 592| Staphylococcus aureus (erythromycin-susceptible + mupirocin-susceptible + oxacillin-susceptible)| ≤2 － ?| 592| Staphylococcus aureus (G19 + methicillin-resistant)| 0.39 － ?| 734| Staphylococcus aureus (G31 + methicillin-resistant)| 0.39 － ?| 734| Staphylococcus aureus (G47 + methicillin-resistant)| 0.39 － ?| 734| Staphylococcus aureus (G6 + methicillin-resistant)| 0.2 － ?| 734| Staphylococcus aureus (G71 + methicillin-resistant)| 0.39 － ?| 734| Staphylococcus aureus (G73 + methicillin-resistant)| 0.39 － ?| 734| Staphylococcus aureus (G81 + methicillin-resistant)| 3.13 － ?| 734| Staphylococcus aureus (G89 + methicillin-resistant)| 0.39 － ?| 734| Staphylococcus aureus (JSB20013)| 0.125 － ?| 748| Staphylococcus aureus (LZ1 + initial)| 4096 － ?| 789| Staphylococcus aureus (LZ10 + initial)| 0.25 － ?| 789| Staphylococcus aureus (LZ10 + methicillin-resistant)| 0.12 － ?| 789| Staphylococcus aureus (LZ6 + initial)| 4096 － ?| 789| Staphylococcus aureus (MB000143 + initial)| 0.06 － ?| 789| Staphylococcus aureus (Meth SA3)| 0.12 － ?| 120| Staphylococcus aureus (Meth SA7)| 0.12 － ?| 120| Staphylococcus aureus (methicillin-resistant + mupirocin-resistant)| 8 － >64| 120| Staphylococcus aureus (methicillin-resistant)| 0.12 － >64| 120| Staphylococcus aureus (methicillin-resistant)| ≤4 － >128| 604| Staphylococcus aureus (methicillin-susceptible)| 0.12 － >16| 120| Staphylococcus aureus (methicillin-susceptible)| ≤4 － ?| 604| Staphylococcus aureus (Mup SA206)| 16 － ?| 120| Staphylococcus aureus (NRS103 + initial)| 0.25 － ?| 789| Staphylococcus aureus (NRS107 + initial)| 4096 － ?| 789| Staphylococcus aureus (NRS116 + initial)| 0.12 － ?| 789| Staphylococcus aureus (NRS8 + initial)| 32 － ?| 789| Staphylococcus aureus (oxacillin-resistant)| ≤2 － >256| 592| Staphylococcus aureus (Oxford)| 0.125 － ?| 101| Staphylococcus aureus (pork isolate + Korea)| >128 － ?| 901| Staphylococcus aureus (RN1024)| 0.25 － ?| 601| Staphylococcus aureus (RN1024-tms)| 0.25 － ?| 601| Staphylococcus aureus (RN4220 + pCU1)| ≤0.06 － ?| 601| Staphylococcus aureus (RN4220 + pCU1vgaAv)| ≤0.06 － ?| 601| Staphylococcus aureus (RN4220 + pVGA)| ≤0.06 － ?| 601| Staphylococcus aureus (RN4220 + pYH4 vector + aTc inducer)| 0.06 － ?| 789| Staphylococcus aureus (RN4220 + pYH4 vector)| 0.06 － ?| 789| Staphylococcus aureus (RN4220 + pYH4-met(S))| 0.06 － ?| 789| Staphylococcus aureus (RN4220 + pYH4-metS + aTc inducer)| 0.006 － ?| 789| Staphylococcus aureus (RN4220/tet(A)/pYH4)| 0.125 － ?| 748| Staphylococcus aureus (S203 + methicillin-resistant)| 0.39 － ?| 734| Staphylococcus aureus (WCUH29)| 0.25 － ?| 101| Staphylococcus auricularis (coagulase-negative + mupirocin-susceptible + oxacillin-susceptible)| ≤2 － ?| 592| Staphylococcus auricularis (coagulase-negative + oxacillin-resistant)| ≤2 － >256| 592| Staphylococcus capitis (coagulase-negative + mupirocin-susceptible + oxacillin-susceptible)| ≤2 － ?| 592| Staphylococcus capitis (coagulase-negative + oxacillin-resistant)| ≤2 － >2556| 592| Staphylococcus epidermidis| 0.12 － >16| 120| Staphylococcus epidermidis (coagulase-negative + mupirocin-susceptible + oxacillin-susceptible)| ≤2 － ?| 592| Staphylococcus epidermidis (coagulase-negative + oxacillin-resistant)| ≤2 － >256| 592| Staphylococcus epidermidis (Mup Sepi25)| >16 － ?| 120| Staphylococcus epidermidis (Mup Sepi26)| >16 － ?| 120| Staphylococcus epidermidis (Sepi 1)| 0.12 － ?| 120| Staphylococcus epidermidis (Sepi 2)| 0.12 － ?| 120| Staphylococcus epidermidis (Sepi 3)| 0.06 － ?| 120| Staphylococcus haemolyticus (coagulase-negative + oxacillin-resistant)| ≤2 － >256| 592| Staphylococcus hominis (coagulase-negative + mupirocin-susceptible + oxacillin-susceptible)| ≤2 － ?| 592| Staphylococcus hominis (coagulase-negative + oxacillin-resistant)| ≤2 － >256| 592| Staphylococcus intermedius (coagulase-negative + oxacillin-resistant)| ≤2 － >256| 592| Staphylococcus lugdunensis (coagulase-negative + mupirocin-susceptible + oxacillin-susceptible)| ≤2 － ?| 592| Staphylococcus lugdunensis (coagulase-negative + oxacillin-resistant)| ≤2 － >256| 592| Staphylococcus pyogenes (erythromycin-resistant)| ≤2 － ?| 592| Staphylococcus saprophyticus| 0.06 － 16| 120| Staphylococcus saprophyticus (coagulase-negative + oxacillin-resistant)| ≤2 － >256| 592| Staphylococcus simulans (coagulase-negative + mupirocin-susceptible + oxacillin-susceptible)| ≤2 － ?| 592| Staphylococcus simulans (coagulase-negative + oxacillin-resistant)| ≤2 － >256| 592| Staphylococcus spp. (coagulase negative)| ≤4 － >128| 604| Staphylococcus warneri (coagulase-negative + mupirocin-susceptible + oxacillin-susceptible)| ≤2 － ?| 592| Staphylococcus warneri (coagulase-negative + oxacillin-resistant)| ≤2 － >256| 592| Streptococci (Viridans group)| 0.25 － >16| 120| Streptococci (β-hemolytic)| ≤4 － ?| 604| Streptococcus agalactiae| 0.25 － 1| 120| Streptococcus agalactiae| ≤4 － ?| 604| Streptococcus pneumonia| 0.12 － 4| 120| Streptococcus pneumonia (G9A)| 0.1 － ?| 313| Streptococcus pyogenes| 0.12 － >16| 120| Streptococcus pyogenes| ≤4 － ?| 604| Streptococcus pyogenes (ATCC 19615 + initial)| 0.06 － ?| 789| Streptococcus pyogenes (Spy 1)| 0.25 － ?| 120| Streptococcus pyogenes (Spy 2)| 0.12 － ?| 120| Streptococcus pyogenes (Spy 3)| 0.25 － ?| 120| Streptococcus pyogenes (Spy 4)| 0.25 － ?| 120| Streptococcus pyogenes (Spy 5)| 0.12 － ?| 120| |
