SKU: P154  / 
    CAS Number: 69394-19-0

    Pentalenic acid

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    Pentalenic acid has been isolated from many Streptomyces sp. as a co-metabolite of the sesquiterpenoid antibiotic pentalenolactone and related natural products. Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family. Pentalenic acid itself is a useful polycyclic skeleton for structural modification. Members of the pentalenolactone family show antitumor, immunosuppressant and antidiabetic effects, but the bioprofile of pentalenic acid is largely unexplored.

    Molecular Formula  C15H22O3
    References

    Masataka I et al (2006)  Syntheses of biologically active natural products and leading compounds for new pharmaceuticals employing effective construction of a polycyclic skeleton. Chem Pharm Bull. 54:765

    Takamatsu S et al (1978)  Studies on the biosynthesis of pentalenolactone, Part II: Isolation of pentalenic acid and pentalenolactone H. Tetrahedron Lett.19:4411

    Takamatsu S (2011)  Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: Hydroxylation of 1-​deoxypentalenic acid mediated by CYP105D7 (SAV7469) of Streptomyces avermitilis. J Antibiot. 64:65