Piliformic Acid is produced by fungi including Xylaria sp. Piliformic acid has mild inhibitory activity against Propionobacterium acnes, inhibiting the P. acnes-induced pro-inflammatory cytokines production in THP-1 cells. Piliformic acid is active against the plant fungal pathogen Colletotrichum gloeosporioides with MIC 2.92 μmol/mL and has antileishmanial activity.
| Molecular Formula | C11H18O4 |
| References |
Anderson JR et al (1985) Metabolites of the higher fungi. Part 22. 2-Butyl-3-methylsuccinic acid and 2-hexylidene-3-methylsuccinic acid from xylariaceous fungi. J Chem Soc Perkin Trans. 1:1481 Barros CB et al (2018) Leishmanicidal compounds of Nectria pseudotrichia, an endophytic fungus isolated from the plant Caesalpinia echinata (Brazilwood). Mem. Inst. Oswaldo Cruz. 113:102 Elias LM et al (2018) The potential of compounds isolated from Xylaria spp. as antifungal agents against anthracnose. Braz. J. Microbiol. 49:840 |
