SKU: P055  / 
    CAS Number: 7722-44-3 (free base)

    Polymyxin E1 sulfate, EvoPure®


    Polymyxin E1 sulfate or colistin A is one of the two major components of polymyxin E (colistin). Polymyxin E1 and E2 are structurally similar and differ only by a fatty acid group at the N-terminus. Polymyxin E1 contains 6-methyloctanoic acid and polymyxin E2 (colistin B) contains 6-methylheptanoic acid. Together, polymyxin E1 and E2 comprise approximately 85% of polymyxin E; however, 13 different polymyxin E components have been indentified.

    Mechanism of ActionPolymyxin E has a bactericidal effect on Gram negative bacteria by interacting with and displacing essential ions in the lipopolysaccharide (LPS) outer cell wall leading to increased permeability and eventually lysis and death of the cell.
    SpectrumPolymyxin E is used primarily against Gram negative bacteria including Pseudomonas aeruginosa, Klebsiella pneumoniae, and multi-drug resistant Enterobacteriaceae,
    Microbiology ApplicationsPolymyxin E1 and E2 (colistin A and B, respectively) can be used individually to study and compare em>in vitro antimicrobial activity with colistin (polymyxin E complex) or other polymyxins.
    Molecular FormulaC53H100N16O13 · xH2SO(lot specific)

    Falagas, M. E. "Colistin: The Revival of Polymyxins for the Management of Multidrug-resistant Gram-negative Bacterial Infections." Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 40.9 (2005): 1333-341. Web. 10 Sept. 2012.

    Bergen, Philip J. et. al. "Colistin Methanesulfonate Is an Inactive Prodrug of Colistin against Pseudomonas Aeruginosa." Antimicrobial Agents and Chemotherapy 50.6 (2006): 1953-958. Web. 5 Oct. 2012.

    Leifert C., Ritchie J.Y. and Waites W.M., Contaminants of plant-tissue and cell cultures. World Journal of Microbiology and Biotechnology, Vol. 7, pp. 452-469, 1991.

    MJ Mueller, W Brodschelm. "Signaling in the elicitation process is mediated through the octadecanoid pathway leading to jasmonic acid". Proc. Natl. Acad. Sci. USA Vol. 90, pp. 7490-7494, August 1993.

    Li, Jian, and Roger L. Nation. "Comment On: Pharmacokinetics of Inhaled Colistin in Patients with Cystic Fibrosis." Journal of Antimicrobial Chemotherapy (2006): 222-23. Web. 19 June 2013.

    Decolin, Dominique, and Pierre Leroy. "Hyphenated Liquid Chromatographic Method for the Determination of Colistin Residues in Bovine Tissues." N.p., n.d. Web. 19 June 2013.