Polymyxin E1 sulfate or colistin A is one of the two major components of polymyxin E (colistin). Polymyxin E1 and E2 are structurally similar and differ only by a fatty acid group at the N-terminus. Polymyxin E1 contains 6-methyloctanoic acid and polymyxin E2 (colistin B) contains 6-methylheptanoic acid. Together, polymyxin E1 and E2 comprise approximately 85% of polymyxin E; however, 13 different polymyxin E components have been indentified.
|Mechanism of Action||Polymyxin E has a bactericidal effect on Gram negative bacteria by interacting with and displacing essential ions in the lipopolysaccharide (LPS) outer cell wall leading to increased permeability and eventually lysis and death of the cell.|
|Spectrum||Polymyxin E is used primarily against Gram negative bacteria including Pseudomonas aeruginosa, Klebsiella pneumoniae, and multi-drug resistant Enterobacteriaceae,|
|Microbiology Applications||Polymyxin E1 and E2 (colistin A and B, respectively) can be used individually to study and compare em>in vitro antimicrobial activity with colistin (polymyxin E complex) or other polymyxins.|
|Molecular Formula||C53H100N16O13 · xH2SO4 (lot specific)|
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