SKU: P055  / 
    CAS Number: 7722-44-3 (free base)

    Polymyxin E1 Sulfate, EvoPure®

    $894.86

    Polymyxin E1 Sulfate (syn: colistin A) is one of the two major components of Polymyxin E (colistin). Polymyxin E1 and E2 are structurally similar and differ only by a fatty acid group at the N-terminus. Polymyxin E1 contains 6-methyloctanoic acid and Polymyxin E2 (colistin B) contains 6-methylheptanoic acid. Together, Polymyxin E1 and E2 comprise approximately 85% of Polymyxin E; however, 13 different Polymyxin E components have been indentified.

    We also offer:

    • Polymyxin B Sulfate, USP (P007)
    • Polymyxin B1 Sulfate, EvoPure® (P037)
    • Polymyxin B1-I Sulfate, EvoPure® (P038)
    • Polymyxin B2 Sulfate, EvoPure® (P039)
    • Polymyxin B3 Sulfate, EvoPure® (P040)
    • Polymyxin B6 Sulfate, EvoPure® (P054)
    • Polymyxin E1 Sulfate, EvoPure® (P055)
    • Polymyxin E2 Sulfate, EvoPure® (P056)

    EvoPure® products are purified single antibiotic fractions, most are >99% pure. Highly pure EvoPure® Polymyxin products can be used to analyze the specifc effects of individual Polymyxin B fractions.

    Mechanism of Action Polymyxin E has a bactericidal effect on Gram-negative bacteria by interacting with and displacing essential ions in the lipopolysaccharide (LPS) outer cell wall leading to increased permeability and eventually lysis and death of the cell.
    Spectrum Polymyxin E is used primarily against Gram-negative bacteria including Pseudomonas aeruginosa, Klebsiella pneumoniae, and multi-drug resistant Enterobacteriaceae,
    Microbiology Applications Polymyxin E1 and E2 (colistin A and B, respectively) can be used individually to study and compare in vitro antimicrobial activity with Colistin (Polymyxin E complex) or other polymyxins.
    Molecular Formula C53H100N16O13 · xH2SO(lot specific)
    References

    Falagas ME (2005)  Colistin: The revival of polymyxins for the management of multidrug-resistant Gram-negative bacterial infections. Clinical Infect. Dis. 40(90):1333-1341  PMID 15825037

    Bergen PJ et al (2006)  Colistin Methanesulfonate is an inactive prodrug of Colistin against Pseudomonas aeruginosa.  Antimicrob. Agents Chemother. 50(6):1953-1958  PMID 16723551 

    Decolin D, Leroy P, Nicolas A, Archimbault P (1997)  Hyphenated liquid chromatographic method for the determination of colistin residues in bovine tissues. J Chromatogr. Sci. 135(12):557-564  PMID 9397540

    Leifert C, Ritchie JY and Waites WM (1991)  Contaminants of plant-tissue and cell cultures. World J.  Microbiol. Biotechnol. 7:452-469  PMID 24425131

    Mueller MJ and Brodschelm W (1993)  Signaling in the elicitation process is mediated through the octadecanoid pathway leading to jasmonic acid. Proc. Natl. Acad. Sci. USA 90:7490-7494