SKU: P095  / 
    CAS Number: 12650-69-0

    Pseudomonic acid

    $184.17 - $644.57
    Pseudomonic acid is a potent antibiotic produced by Pseudomonas fluorescens, reported by Fuller et al. in 1971. Pseudomonic acid has broad spectrum activity against Gram positive bacteria and was approved for topical human use in 1985.

    Pseudomonic acid is soluble in ethanol, methanol, DMF and DMSO.
    Mechanism of ActionPseudomonic acid acts as a potent and selective inhibitor of isoleucyl-tRNA synthetase.
    ReferencesPseudomonic acid: an antibiotic produced by Pseudomonas fluorescens. Fuller A.T. et al. , Nature 1971, 234, 416.

    Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use. Sutherland R., Antimicrob Agents Chemother. 1985, 27, 495.

    Inhibition of isoleucyl-transfer ribonucleic acid synthetase in Echerichia coli by pseudomonic acid. Hughes J. & Mellows G., Biochem. J. 1978, 176, 305.