Pyrantel Citrate is a thiophene and anthelmintic agent. It has been used to characterize Ancylostoma caninum isolates. It was described in 1965 by researchers at Pfizer. Pyrantel and its analogs (oxantel and morantel) are members of the tetrahydropyrimidine family. Other salt forms include tartrate and pamoate salt, with the pamoate salt frequently used in veterinary research. Pyrantel is a nicotinic agonist for the acetylcholine (ACh) receptor. It is also a cholinesterase inhibitor.
Pyrantel Citrate is freely soluble in water.
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| Mechanism of Action |
Pyrantel Citrate activates the excitatory nicotinic acetylcholine (nACh) receptor causing spastic paralysis of suceptible nematodes. |
| Spectrum | Pyrantel Citrate has activity against parasites including pinworm, hookworm, roundworm and others. |
| Molecular Formula | C11H14N2S · C6H8O7 |
| References |
Kopp SR et al (2008) Pyrantel in small animal medicine: 30 years on. Vet. J. 178(2):177-184 Sheehan DJ, Sheehan SM, and Marchiondo AA (2016) Discovery and chemistry of Pyrantel, morantel and oxantel. In: Pyrantel Parasiticide therapy in humans and domestic animals. Ch. 1 pp. 1-19 Martin RJ and Geary TG (2016) Pharmacology of Pyrantel. In: Pyrantel parasiticide therapy in humans and domestic animals. Ch.2. pp. 21-45 |
