Quinine Sulfate is used to study the metabolism of hemozoin in malarial parasites. It is also used to study the toxicity of heme complexes.
Quinine, a naturally occurring alkaloid, was isolated from the bark of the cinchona tree circa 1820. It is a stereoisomer of quinidine which contains an aromatic quinoline and a bicyclic quinuclidine. A potassium channel blocker and anti-malarial compound, Quinine can be used as an analytical reference standard. Bark extracts have been used for malaria since 1632 (Sullivan, 2011) and Quinine was the very first antimalarial discovered over 400 years ago. Quinine is also used in nutrition resarch as a bitterness standard.
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| Mechanism of Action | Quinine Sulfate Inhibits the mitochondrial ATP-regulated potassium channel. |
| Molecular Formula | C20H24N2O2 ∙ 0.5H2O4S ∙H20 |
| References | Holfels E et al. “In vitro effects of artemisinin ether, cycloguanil hydrochloride (alone and in combination with sulfadiazine), quinine sulfate, mefloquine, primaquine phosphate, trifluoperazine hydrochloride, and verapamil on Toxoplasma gondii .” Antimicrobial Agents and Chemotherapy 38.6 (1994): 1392–1396 |
