SKU: R002  / 
    CAS Number: 53797-35-6

    Ribostamycin Sulfate

    $285.00 - $621.00

    Ribostamycin is an aminoglycoside antibiotic and is freely soluble in aqueous solution at 88.7 mg/mL.

    Ribostamycin is an aminoglycoside-aminocyclitol antibiotic isolated from Streptomyces ribosidificus, originally from a soil sample in Japan.  It is an mportant broad-spectrum antibiotic with important use against human immunodeficiency virus. Resistance to aminoglycosides is a growing concern.

    Mechanism of Action Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.
    Microbiology Applications  Resistance is due to bacterial enzymes that modify the structure through phosphorylation, adenylation, and acetylation and prevent the antibiotic from being able to interact with the bacterial rRNAs.
    Spectrum Ribostamycin is a broad spectrum antibiotic targeting a wide range of gram positive and gram negative bacteria.
    Molecular Formula C17H34N4O10 · H2SO4

    Davis BD (1987)  Mechanism of bactericidal action of Aminoglycosides. Microbiol. Rev. 51.3:341-50.

    MIC Borrelia burgdorferi S.L.| 8 - 64|| Escherichia coli| 8 - 12.5||