Roccellic Acid is a secondary metabolite and methyldodecylsuccinic acid isolated from lichen Roccella spp. over 150 years ago, with the structure fully elucidated by Akermark in 1962. Roccellic Acid is active against the oral bacteria, Streptococcus gordonii and Porphyromonas gingivalis. It has antibcterial and anticancer activities.
| Molecular Formula | C17H32O4 |
| Cancer Applications | Roccellic Acid inhibits proliferation of cancer cells. In a system with the compound at 100 µg/ml, it inhibited the proliferation of MDA-MB-231, MCF-7, and DLD-1 cancer cells by 65.3, 75.8, and 87.9%, respectively (Sweiden et al, 2017). |
| References |
Akermark B (1962) Studies on chemistry of lichens 16. Absolute configuration of Roccellic Acid. ACTA Chemica Scandinavica 16(3):599 Fox CH and Huneck S (1969) The formation of Roccellic Acid, eugenitol, eugenetin, and rupicolon by the mycobiont Lecanora rupicola. Phytochem. 8:1301 Isolation and identification of cytotoxic compounds from a fruticose lichen Roccella montagnei, and its in silico docking study against CDK- Sweiden A et al (2017) Antibacterial activities of natural lichen compounds against Streptococcus gordonii and Porphyromonas gingivalis. Fitoterapia 121:164 |
