Inhibitor

Ceftazidime Hydrochloride

Ceftazidime Hydrochloride is a non-toxic hydrochloride salt derivative of Ceftazidime, a broad-spectrum, third-generation, β-lactam cephalosporin that interferes with bacterial cell wall synthesis.  Patented in 1979 by Glaxo Group, it came into...

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Micafungin Sodium

Micafungin Sodium is the sodium salt of the semi-synthetic cyclic lipopeptide Micafungin.  Micafungin is an antifungal compound belonging to the antifungal class known as echinocandins.  It was reported in 1999 by Fujisawa (Japan).  It is...

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O-Methylviridicatin

O-Methylviridicatin is a natural derivative of the alkaloid mycotoxin viridicatin produced by several species of Penicillium.  The scaffold of quinolin-2(1H)-one is a useful structural motif found in many natural products.  In particular,...

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Kazusamycin B

Kazusamycin B is a metabolite and minor member of the Leptomycin complex isolated from some Streptomyces species. It is a hydroxylated analog of Leptomycin A, a nuclear export inhibitor. It is similar to Leptomycins A and B in physico-chemical and...

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Tenofovir Alafenamide

Tenofovir alafenamide is an antiretroviral developed by Gilead and the anti-HIV  activity was reported  in 1993.  It is an investigational precursor to Tenovor, a nucleotide reverse transcriptase inhibitor.  Tenofovir alafenamide is...

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Anguinomycin A

Anguinomycin A is a natural polyketide and analog of Leptomycin B, an inhibitor of protein nuclear export.  It is isolated from Streptomyces spp., and displays anti-cancer activity.  Anguinomycins B, C and D are also members of the Leptomycin...

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Kazusamycin A

Kazusamycin A is a minor member of the Leptomycin complex isolated from some Streptomyces species. It is a hydroxylated analog of Leptomycin B, a nuclear export inhibitor. It is similar to Leptomycins A and B in physico-chemical and biological...

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Leptomycin B

Leptomycin B is the dominant member of the Leptomycin class, secondary metabolites isolated from selected Streptomyces strains.  It is a bioactive small molecule with antifungal and antibacterial activity.  It is a nuclear export inhibitor,...

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Miconazole Nitrate

Miconazole Nitrate is the nitrate salt of Miconazole, an imidazole antimycotic compound patented in 1968 (Janssen Pharmaceutica).  It targets the fungi that cause tinea (ringworm) and athlete’s foot.  It inhibits ergosterol synthesis, and...

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Anidulafungin

Anidulafungin is a semi-synthetic echinocandin derivative and antifungal effective against Candida spp.   Anidulafungin inhibits fungal cell wall synthesis. It is useful in pharmacotherapy and cell culture research applications.  It is...

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Amphotericin B, USP

Amphotericin B, USP (syn: Fungizone) is a polyene macrolide aminoglycoside broad-spectrum antimycotic.  This bioactive natural product was isolated from soil collected from Orinoco River (Venezuela) in 1955 and identified as Streptomyces nodosus by...

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Clotrimazole

Clotrimazole is a broad-spectrum antifungal belonging to the imidazole subclass of azole compounds. These compounds interfere with the biosynthesis of ergosterol, a major membrane component of the fungal cytoplasmic membrane. Clotrimazole was discovered...

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