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Ochratoxin B is the non-chlorinated analogue of the much more extensively studied ochratoxin A. It is co-produced by the same species of Aspergillus and Penicillium that are associated with food spoilage. Ochratoxin B has received little focused...
Ochratoxin A is a chlorinated benzopyran coupled to phenylalanine, produced by several Aspergillus and Penicillium sp. associated with food spoilage. Ochratoxins are widely distributed in the environment and are known to be nephrotoxic, teratogenic and...
Ansatrienin A, isolated from a Streptomyces sp., is closely related to the cytotrienins and trienomycins. It displays potent activity against tumor cell lines and inhibits osteoclastic bone resorption. Ansatrienin A also significantly potentiates the...
Ansatrienin B, also known as Mycotrienin II and Antibiotic T 23II, was isolated from a Streptomyces sp.. Closely related to the cytotrienins and trienomycins, it displays potent activity against tumor cell lines and inhibits osteoclastic bone resorption...
Acriflavine Hydrochloride (syn: Acriflavine HCl) is the hydrochloride salt of Acriflavine, a mixture of 3,6-diamino-10-methylacridium (acriflavin) and 3,6-diaminoacridine (proflavin). It was developed in 1912 by Paul Ehrlich, a medical researcher...
Mebendazole is a broad-spectrum anthelmintic used as a treatment for roundworms. More recently it has been investigated as an anti-cancer agent, showing promise in vitro and in mouse models.Mebendazole is soluble in formic acid and practically...
Geninthiocin is a thiopeptide antibiotic isolated from a Streptomyces sp. Geninthiocin displays a 10-fold selectivity for bacteria over mammalian cells lines, whereas the related dedialanyl geninthiocin shows the reverse selectivity. Geninthiocin is...
Aureothin, an unusual pyranone metabolite, has broad biological actions including antitumor, antimicrobial and insecticidal activities. More recently, aureothin has been shown to be a potent inhibitor of Helicobacter pylori.Aureothin is soluble...
Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5, and is an important bioprobe for...
Kigamicin C was discovered by an anti-austerity strategy, targeting cancer cells' tolerance to starvation. It selectively kills PANC-1 cells (a pancreatic cell line) at concentrations 100 times lower under nutrient starved conditions than in normal...
Emodin is a tyrosine kinase inhibitor found in multiple plants with a variety of bioactivity including anti-inflammatory, antiviral, antibacterial and anticancer activity. As an anticancer agent it has drawn attention by showing promising therapeutic...
Chrysomycin B is a minor analogue in a complex of C-glycoside antitumor actives isolated from Streptomyces. Chrysomycin B, containing a methyl group in the 8-position, is less active than its vinyl analogue (Chrysomycin A), albeit still a potent...
