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Tubercidin is a nucleoside metabolite first isolated from Streptomyces tubericidus. Tubercidin, like other nucleosides, is a broad spectrum potent chemotherapeutic agent active against viruses, bacteria, fungi, protozoans and tumors. Soluble in...
Tigecycline is a broad spectrum glycylcycline antibiotic useful for multi-drug resistant organisms and approved by the FDA in June 2005. Tigecycline is a semisynthetic derivative of tetracycline, that is structurally similar to minocycline; however, it...
Antimycin A2 is a homologue of the antimycin complex, first resolved from antimycin A1 in 1959. Antimycin A2, like all antimycins, is a potent inhibitor of respiration by inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A2 exhibits broad...
Antimycin A3 is an homolog of the Antimycin complex (syn: Antimycin A). Antimycin A3 is one of four closely related structures in the mixture (others include Antimycin A1, A2 and A4). First isolated in 1958 from Streptomyces blastimyceticus...
Bithionol is an anti-parasitic drug and has recently been found to have anti-ovarian cancer properties. In one study, bithionol inhibited all tested ovarian cancer cell lines with IC50 values from 19 µM - 60 µM.Mechanism of ActionThe mechanism of action...
Antimycin A4 is the most polar of the major components of the antimycin complex, first isolated in 1958 from Streptomyces blastimyceticus and co-produced with antimycin A3. Antimycin A4 exhibits broad biological activity as an antifungal, anthelmintic,...
Enniatins are a family of depsipeptide ionophores, produced by several Fusarium species. Recently, the effects of the enniatins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus...
Antimycin (syn: Antimycin A) is a complex of related macrocyclic lactones, predominantly A1 to A4, isolated from several species of Streptomyces, first reported in the early 1950s for potent antifungal activity. There are over 20 known analogs in the...
Enniatins are a family of depsipeptide ionophores produced by several Fusarium species. Recently, the effects of the enniatins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus...
5-Fluorouracil is a synthetic growth inhibitor and a thymidylate synthase (TS) inhibitor. It is named as there is a fluorine atom on the 5th carbon of a uracil ring. Fluorouracil was patented in 1956 (Hoffman La-Roche). Metabolites of...
Enniatins are a complex of depsipeptides produced by several Fusarium species. Typically, the complex contains 4 major components: A, A1, B and B1 together with minor amounts of enniatins C, D, E and F. The enniatins act as ionophores. Recently their...
