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Monactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. Monactin has not previously been available for intensive investigation. Early literature reported that the related dinactin is a monovalent cation ionophore...
Icotinib is an anticancer agent. Icotinib acts as an inhibitor of mutated, overactive or overexpresssed epidermal growth factor receptor (EGFR). Because epidermal growth factors are responsible for controlling cell growth and proliferation, a mutated...
Dacarbazine is an alkylating antineoplastic agent, a chemotherapy drug used in the treatment of numerous cancers including Hodgkin's lymphoma.Mechanism of ActionWhen converted to its active form, dacarbazine methylates the DNA base guanine at the O-6...
Flurbiprofen is a non-steroidal anti-inflammatory compound (NSAID). Flurbiprofen is practically insoluble in water, and freely soluble in ether and methanol.This product is considered a dangerous good. Quantities above 1 g may be subject to...
Icaritin is a hydrolytic product of icariin, and one of the bioactive components of the epimedium genus. It has gained interest mainly from its anticancer activity, including its ability to slow the growth of cancer cells and induce apoptosis. Icaritin...
Acalabrutinib is a highly selective, irreversible inhibitor of Bruton's tyrosine kinase (BTK), and is being considered for use in the treatment of relapsed chronic lymphoid leukemia. Mutations in BTK result in a variety of B-cell related malignancies, as...
Bleomycin (Syn: Bleomycin Complex) is a complex of 11 glycopeptide antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components are Bleomycin A2 and Bleomycin B2, which typically represent >90% of the total...
Hydroxyurea is an antineoplastic chemotherapeutic compound used in sickle cell anemia studies and cancer research, including leukemia, skin cancer, and ovarian cancers.Hydroxyurea is freely soluble in water. Mechanism of Action Hydroxyurea...
Indomethacin is a part of the non-steroidal anti-inflammatory compound (NSAID) class, and as such exhibits anti-inflammatory, antipyretic and analgesic properties. Indomethacin has also demonstrated the ability to inhibit cell growth and induce apoptosis...
O-Deacetylravidomycin is the more active and stable analogue of the ravidomycin complex produced by Streptomyces ravidus. The metabolite shows potent, light-dependent antitumor activity. O-Deacetylravidomycin, like the related gilvocarcins and...
Flumethasone is a topical corticosteroid of the glucocorticoid class used in the treatment of skin disorders where it reduces inflammation.Flumethasone is insoluble in water.Molecular FormulaC22H28F2O5ReferencesAbdel-Aleem, E. A., Hegazy, M. A., Sayed, N...
Ingenol-3-mebutate is an anticancer agent isolated from Euphorbia peplus used in the treatment of Actinic keratosis. Researchers have shown interest in expanding its anticancer activity, finding promise in its ability to promote proapoptotic effects in...