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Cefuroxime is a semi-synthetic, broad-spectrum, β-lactamase-resistant, second-generation cephalosporin. The compound was patented in 1971. It has increased stability to β-lactamases, which can widen the spectrum so that many organisms that are...
Cefoperazone Free Acid is a semi-synthetic, broad-spectrum third-generation cephalosporin. Patented in 1974, it was marketed by Pfizer under the trade name Cefobid. The compound has activity against Pseudomonas. It has a tetrazolyl moiety that confers...
Syringic Acid, the 3,5-dimethyl ether derivative of gallic acid, is a phenolic compound found in fruits and vegetables which is synthesized via the shikimic acid pathway in plants. Syringic Acid has a broad bioprofile, having antioxidant,...
Pikromycin was the first macrolide antibiotic, isolated in 1951 by the German researchers Brockmann and co-workers from Streptomyces sp. Its structure as a 14-membered lactone linked to D-desosamine was confirmed in 1957. Pikromycin is synthesized...
Pactamycin (syn: Pactacin) is a unique type of highly-substituted aminocyclitol produced by Streptomyces sp. which is a potent inhibitor of translation in eukaryotes, bacteria and archaea, active against Gram-positive and Gram-negative bacteria. ...
Neosartoricin B was produced biosynthetically in 2013 by Tang and colleagues from UCLA USA by selecting the gene cluster for neosartoricin that is homologous to a conserved cluster among dermatophytes of the Trichophyton and Arthroderma genera. When...
Neosartoricin is a carbotricyclic metabolite produced by Aspergillus fumigatus and Neosartorya fischeri following activation of their polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters, reported by Tang and...
The nanangenines are newly discovered drimane sesquiterpenoid metabolites from a hitherto undescribed Australian fungus, Aspergillus nanangensis. Nanangenine H is an acylated drimane which is a putative biosynthetic intermediate of the higher nanagenines...
The nanangenines are newly discovered drimane sesquiterpenoid metabolites from a hitherto undescribed Australian fungus, Aspergillus nanangensis. Nanangenine G is an acylated drimane which is a putative biosynthetic intermediate of the higher...
The nanangenines are newly discovered drimane sesquiterpenoid metabolites from a hitherto undescribed Australian fungus, Aspergillus nanangensis. Nanangenine F is an acylated drimane and putative biosynthetic intermediate of the higher nanangenines...
The nanangenines are newly discovered drimane sesquiterpenoid metabolites from a hitherto undescribed Australian fungus, Aspergillus nanangensis. Nanangenine D is a drimane lactone bearing a C8 acyl side chain. Nanangenine D has potent activity against B...
The nanangenines are newly discovered drimane sesquiterpenoid metabolites from a hitherto undescribed Australian fungus, Aspergillus nanangensis. Nanangenine D is a drimane lactone bearing a C6 acyl side chain. Nanangenine D has potent activity against B...