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Artemisinin is a sesquiterpene lactone isolated from the aerial parts of Artemisia annua L.. Artemisin is best known for its activity against the malaria parasite including resistant strains, but also has antitumor, immunomodulatory and...
Ansamitocins, a new group of ansamycin antibiotics with potent antitumor activity, were first reported in the journal Nature in 1977 by researchers from Takeda Chemical Industries. Anisomitocin P3 is the 3-O-methylpropanoyl derivative of maytansinol...
Anagyrine is a teratogenic quinolizidine alkaloid found in Lupinus sp. which undergoes metabolism to a piperidine that causes crooked calf syndrome. Anagyrine, but not lupanine or sparteine, directly desensitize nicotinic acetylcholine receptors (nAChR)...
Aminopterin is a 4-amino derivative of folic acid and a folic acid antagonist. It is a synthetic derivative of pterin. It has both mmunosuppressive properties and anti-cancer properties and can be used for apoptosis research. The compound was discovered...
Actinonin is a metabolite of Streptomyces roseoplallidus and other Streptomyces species, first reported in Nature in 1962. Actinonin is a bacteriostatic agent with activity against Gram-positive and fastidious Gram-negative microorganisms. Actinonin...
Acadesine was originally identified as a metabolite of Bacillus species and was shown to accumulate in the culture medium of E. coli under sulphonamide stasis. Acadesine is an adenosine-regulating agent that increases bioavailability of adenosine. Ithas...
Floramultine was first isolated from Kreysigia multiflora, a member of the Liliacaeae family, in 1960 by Badger and Bradbury, University of Adelaide, Australia. The absolute configuration of (-)-floramultine was later published by Lamberton and...
5-Methoxycanthinone is a β-carboline first isolated from the Australian Rutaceae Pentaceras Australis Hook by Price and co-workers at the CSIRO, Australia in 1952. 5-Methoxycanthinone is a modest inhibitor of a panel of the human tumor cell lines:...
4’-Acetylchrysomycin B and its co-metabolite, 4’-acetylchrysomycin A, were isolated during a screen for antitumor agents. Acetylation of chyrsomycin B increase cytotoxicity. Acetylchyrsomycins are active against Gram-positive bacteria,...
4'-Acetylchrysomycin C is a methylated analogue of 4'-acetylchrysomycin A. To date there are no reports of the biological activity of 4-acetylchrysomycin C in the literature. Molecular Formula C30H32O10 References Wada S et al (2017) ...
3-Hydroxy-L-tyrosine methyl ester (melevodopa, L-dopa methyl ester) is a prodrug of levodopa used for the treatment of Parkinson’s disease. L-DOPA methyl ester is a potent competitive antagonist for the action of L-DOPA...
2-Benzoxazolinone is a metabolite produced by rye (Secale cereale) that inhibits germination and growth and causing oxidative damage. 2-Benzoxazolinone has diverse pharmacological activities including antinociception, anti-inflammatory,...
