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Nisin Z is a natural bacteriocin polypeptide antibiotic known as a lantibiotic. It is a 34-amino acid polycyclic antibacterial peptide. Nisin Z and Nisin A (Nisin) are two naturally occurring variants of Nisin that are produced by fermentation of...
Anacardic acid is a histone acetyltransferase (HAT) inhibitor that is derived from cashew shells. Anacardic acid is associated with anti-inflammatory, anti-tumor, molluscicidal, and anti-microbial activity. Anacardic acid is a common inhibitor of several...
Heronamide C is an unusual polyene macrocyclic lactam containing two isolated tetraene and triene chromophores. Heronamide C induces a unique reversible vacuolisation of mammalian tumor cells.Heronamide C is soluble in DMF or DMSO. Moderately...
Cryptotanshinone is one of several bioactive tanshinones extracted from the Chinese medicinal herb, Salvia mitiorrhiza. It exhibits a variety of bioactivity including antibacterial, antioxidant and anti-inflammatory effects, but has more recently gained...
Staurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumor active, inducing apoptosis in a variety of cell lines. At submicromolar concentrations, staurosporine inhibits both IKKalpha and...
Micrococcin P1 is a macrocyclic thiopeptide originally isolated from Micrococcus sp. by Su (Oxford) in 1948 and is considered the founding member of the thiopeptide antibiotic family. It was purified by Heatley and Doery but the producing strain...
Dihydrotanshinone I is one of many bioactive products isolated from Salvia miltiorrhiza, a well-known traditional Chinese medicinal plant. It's primary promise lies in its anticancer activity, but it has been found to be active against gram-positive...
The tunicamycins are a family of lipophilic nucleosides with fatty acids conjugated to an aminoglycoside group. The complex comprises the analogues, tunicamycins I to X. This composition is typical of other products less precisely described as...
Plumieride is a widely bioactive compound able to be isolated from several plants. Plumieride specifically is cytotoxic, and essential oils and ethanol extracts of plants containing Plumieride have been found to act as a diuretic, antibacterial,...
Miltefosine is primarily used as an antileishmanial drug with demonstrated activity against other parasites, cancer cells, and pathogenic bacteria and fungi.Mechanism of ActionSeveral potential antileishmanial mechanisms of action have been proposed...
O-Methylsterigmatocystin is a natural product formed via methylation of sterigmatocystin. O-Methylsterigmatocystin is a xanthone metabolite isolated from several species of Aspergillus and Chaetomium. It is a precursor to aflatoxin G1 and B1 and,...
Embelin is a benzoquinone derivative from the Japanese Ardisia herb. It is a cell-permeable, small-molecule inhibitor of apoptosis regulator proteins. It is a promising start to a new class of anticancer drugs that target apoptosis regulator proteins. It...