Antitumor

Kazusamycin A

Kazusamycin A is a minor member of the Leptomycin complex isolated from some Streptomyces species. It is a hydroxylated analog of Leptomycin B, a nuclear export inhibitor. It is similar to Leptomycins A and B in physico-chemical and biological...

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PC-766B

PC-766B is a 16-membered macrolide antibiotic produced by Nocardia brasiliensis, reported by researchers at Sumitomo in 1993. Structurally, PC-766B is a member of bafilomycin class, featuring a rare butadiene side-chain. PC-766B is active against Gram...

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Leptomycin B

Leptomycin B is the dominant member of the Leptomycin class, secondary metabolites isolated from selected Streptomyces strains.  It is a bioactive small molecule with antifungal and antibacterial activity.  It is a nuclear export inhibitor,...

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Menadione Sodium Bisulfite

Menadione Sodium Bisulfite (syn: Vitamin K3) is the metabolic precursor to Vitamin K2 in mammals. It belongs to the class 1,4-naphthoquinones, specifically a 1,4-naphthoquinone, which is substituted at position 2 by a methyl group.  It is a possible...

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Chaetocin

Chaetocin is an epithiodioxopiperazine antibiotic that has recently shown promise as a selective antitumor agent. Chaetocin is dramatically accumulated in cancer cells via a process inhibited by glutathione. Inside the cell, its activity is mediated by...

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Menadione

Menadione (Vitamin K3) is the precursor to vitamin K2 in mammals.  It has also been tested as a possible anticancer agent able to induce apoptosis.  Menadione is suitable for microbiology use. We also offer: Menadione sodium bisulfite...

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Kijanimicin

Kijanimicin is a tetronic acid related to saccharocarcin, chlorothricin, versipelostatin and tetrocarcin. Like the tetrocarcins, kijanimicin contains an unusual nitroaminoglycoside. Kijanimicin is a potent antibacterial, antimalarial and antitumor active...

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Albofungin

Albofungin is a polyaromatic heterocycle containing a rare N-aminoamide, isolated from a Streptomyces species in Russia in 1959. Albofungin exhibits a broad biological profile with antibiotic, antifungal, anthelmintic and very potent antitumor activity...

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Doxorubicin

Doxorubicin (syn: Adriamycin) is the most extensively studied of a family of highly fluorescent anthracycline antibiotics produced by several Streptomyces species, first reported in 1967 and later approved for human therapeutic use as an antitumor agent...

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Cytochalasin J

Cytochalasin J is one of a family of potent mycotoxins produced by a range of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, which give rise to pronounced morphogenic activity in animals and plants. Cytochalasin J is...

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Apoptolidin

Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene (IC50 = 11 ng/ml). Apoptolidin is among the most selective cytotoxic agents tested by the NCI in human...

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Epiequisetin

Epiequisetin is a minor isomer of equisetin, a potent inhibitor of HIV-integrase produced by a number of species of Fusarium. Chemically, equisetin equilibrates with epiequisetin. Although found to have comparable phytotoxicity to equisetin, epiequisetin...

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