Antimicrobials

Ansamitocin P3

Ansamitocins, a new group of ansamycin antibiotics with potent antitumor activity, were first reported in the journal Nature in 1977 by researchers from Takeda Chemical Industries. Anisomitocin P3 is the 3-O-methylpropanoyl derivative of maytansinol...

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Anandamide

Anandamide is an endogenous ligand for the cannabinoid receptor. Anandamide activates receptor-​mediated signal transduction and stimulates arachidonic acid and intracellular calcium release in both CHOm5 and CHO-​HCR cells. More recent research has...

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Anagyrine

Anagyrine is a teratogenic quinolizidine alkaloid found in Lupinus sp. which undergoes metabolism to a piperidine that causes crooked calf syndrome. Anagyrine, but not lupanine or sparteine, directly desensitize nicotinic acetylcholine receptors (nAChR)...

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Amycolatopsin C

Amycolatopsin C is a glycosylated polyketide isolated by Microbial Screening Technologies from Amycolotopsis sp.. The amycolatopsins are closely related to the ammocidins and apoptolidins. Amycolatopsin A and C, bearing a hydroxyl group at the 6-methyl...

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Amycolatopsin B

Amycolatopsin B is a glycosylated polyketide isolated by Microbial Screening Technologies. The amycolatopsins are closely related to the ammocidins and apoptolidins. Amycolatopsin A and C, bearing a hydroxyl group at the 6-methyl position, selectively...

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Amycolatopsin A

Amycolatopsin A is a glycosylated polyketide isolated by Microbial Screening Technologies from Amycolotopsis sp.  The amycolatopsins are closely related to the ammocidins and apoptolidins. Amycolatopsin A and C, bearing a hydroxyl group at the...

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Aminopterin

Aminopterin is a 4-amino derivative of folic acid and a folic acid antagonist. It is a synthetic derivative of pterin. It has both mmunosuppressive properties and anti-cancer properties and can be used for apoptosis research. The compound was discovered...

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Ambuic Acid

Ambuic acid is an antifungal cyclohexanone metabolite produced by Pestalotiopsis sp. Ambuic acid inhibits the biosynthesis of quorum sensing peptides in Gram-positive bacteria. Ambuic acid may exert anti-​inflammatory action by blocking the...

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Alternariol monomethylether

Alternariol monomethylether was first reported by Raistrick and colleagues in 1953. Alternariol and its monomethyl ether analogue occur in mycelium of Alternaria tenuis responsible for alternaria cone disorder in hops and fruit spot on papaya (Carica...

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Alternariol

Alternariol is a mycotoxin produced by Alternaria and is often found as a contaminant in fruit and small grain cereal products.  Structurally, it is characterized as a dibenzopyranone.  It can be used as an analytical standard.  The...

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Actinonin

Actinonin is a metabolite of Streptomyces roseoplallidus and other Streptomyces species, first reported in Nature in 1962. Actinonin is a bacteriostatic agent with activity against Gram-positive and fastidious Gram-negative microorganisms. Actinonin...

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Aclarubicin

Aclarubicin (aclacinomycin A) is an anthracycline and topoisomerase II inhibitor that has been clinically tested against haematologic and solid tumors. Aclarubicin stabilizes topoisomerase I cleavage. Aclarubicin accumulates efficiently in the...

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