Antimicrobials

Manumycin A

Manumycin A was isolated by Zeeck and colleagues at the University of Gottingen, Germany published in 1987. Manumycin A is a potent and selective inhibitor of Ras farnesyl transferase. Manumycin A induces apoptosis and inhibits angiogenesis, and has...

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Novobiocic Acid

Novobiocic Acid is a member of the novobiocin aminocoumarin antibiotic family. Novobiocic Acid is a key intermediate in the biosynthesis of novobiocin and an important acid degradation product. While novobiocic Acid exhibits little antibacterial...

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Polygodial

Polygodial is a sesquiterpene dialdehyde first isolated from Persicaria hydropiper (syn. Polygonum hydropiper) by Loder atCSIRO, Australia in 1962. Polygodial is widely distributed, occurring in the roots, bark and leaves of several trees, in plants and...

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Strychnospermine

Strychnospermine is an alkaloid isolated by Ritchie et al. at the University of Sydney, Australia from the Australian native strychnine tree, Strychnos psilosperma, in 1950. There are no published reports of the biological activity of Strychnospermine. ...

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Seselin

Seselin is a pyranocoumarin isolated from the fruits of Seseli indicum by Spath and colleagues in 1939. Seselin wassubsequently isolated from a number of fruits of diverse species, most notably star anise. More recently, Seselin has beenisolated...

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Stachybotrysin B

Stachybotrysin B is an analogue of a complex of phenylspirodrimanes isolated from the fungus, Stachybotrys chartarum, by collaborating Chinese Key Research Institutes in 2017. Stachybotrysin B is active against HIV but is not cytotoxic.Stachybotrysins...

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Sparsomycin

Sparsomycin is a nucleotide analogue produced by Streptomyces sparsogenes isolated by researchers at Upjohn (now Pfizer) in 1962. Sparsomycin binds to the 50S ribosomal subunit and inhibits protein synthesis via peptidyl transferase inhibition. ...

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Sartorypyrone B

Sartorypyrone B is a pentacyclic meroterpenoid metabolite isolated from Aspergillus (syn. Neosartorya) species. Whilesartorypyrone B possesses no antibiotic activity against S. aureus, P. aeruginosa. B. subtilis and E. coli, it is nonethelessscapable of...

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Streptimidone

Streptimidone (protomycin) is a glutarimide antibiotic isolated from Streptomyces spp. first reported in 1959. Streptimidone is active against a wide spectrum of fungi and protozoans, including Entamoeba hystolica in vitro and in vivo. Streptimidone also...

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Terrelulamide A

Terrelulamide A is a rare lumazine pseudo-tripeptide metabolite isolated from a marine strain of Aspergillus terreus byresearchers at Seoul National University, Korea reported in 2015. Terrelulamide A is reported as having metabolic effects and improves...

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Terpendole I

Terpendole I is a polar analog of a rare family of indolediterpenes isolated from Albophoma yamanashiensis, first reported by Omura and colleagues at the Kitasato Institute, Japan in 1995. Terpendole I is a weak inhibitor of ACAT (acylCoA:cholesterol...

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Tropodithietic Acid

Tropodithietic Acid is a potent antibiotic isolated from a Roseobacter strain by Brinkhoff and colleagues at the University of Gottingen, Germany in 2004. Tropodithietic Acid is a strong inhibitor of marine bacteria, promoter of algal health and a potent...

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