Antimicrobials

Orfamide A

Orfamide A is the major component of a family of cyclic lipopeptides produced by Pseudomonas fluorescens, reported in 2007. The orfamides were discovered by employing genomic analysis with an isotope-guided fractionation to identify metabolites produced...

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UCN-02

UCN-02 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms.UCN-02 is...

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UCN-01

UCN-01 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture. UCN-01 enhances the cytotoxicity of other anti-cancer drugs, such as DNA-damaging agents and anti-metabolite drugs, through putative abrogation of G2 and/or S...

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Thiocillin I

Thiocillin I is the simplest of the macrocyclic thiazole peptides, first isolated from Bacillus badius. The final structural assignment and total synthesis of thiocillin I was only completed in 2011. Thiocillin I was originally reported as a potent...

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Sporidesmolide V

Sporidesmolide V is the most non-polar of the N-methyl analogues belonging the hexadepsipeptide sporidesmolide complex. Biosynthesis of sporidesmolide V involves the use of D- and L- amino acids utilising alloisoleucine, isoleucine, leucine, and two...

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Sporidesmolide III

Sporidesmolide III is the only non-N-methylated analogue of the hexadepsipeptide sporidesmolide complex, eluting in advance of the more abundant N-methyl analogues on reverse phase HPLC. Sporidesmolide III is the demethyl analogue of sporidesmolide I and...

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Sporidesmolide II

Sporidesmolide II is the most abundant of N-methyl analogues belonging to the hexadepsipeptide sporidesmolide complex. Biosynthesis of sporidesmolide II involves the use of D- and L- amino acids utilising D-alloisoleucine, leucine and four valine...

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Sporidesmolide I

Sporidesmolide I is the most polar of N-methyl analogues belonging the hexadepsipeptide sporidesmolide complex. Biosynthesis of sporidesmolide I involves the use of D- and L- amino acids utilising two leucine and four valine sub-units, where two of the...

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Sporidesmolide

Sporidesmolide is a family of five closely related cyclic depsipeptides produced by Pithomyces chartarum, the pathogen responsible for facial eczema in sheep, first reported by Russell and colleagues at CSIR in New Zealand in 1961. Sporidesmolide complex...

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Spiramycin I

Spiramycin I (foromacidin A) is the major analog of a complex of 16-membered macrocyclic lactones produced by S. ambofaciens and S. spiramyceticus that have broad spectrum antibiotic activity. Spiramycins are unusual among the macrocyclic lactones in...

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Setosusin

Setosusin is an unusual bis-spiro metabolite originally isolated from Corynascus setosus. There is little published information on the biological profile of this metabolite.Setosusin is soluble in ethanol, methanol, DMF and DMSO.

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(+)-Rugulosin

(+)-Rugulosin is an intense yellow pigment produced by some species of Penicillium, Aspergillus and the fungal symbiotants of some lichens. As an anthraquinoid mycotoxin, (+)-Rugulosin shows antibacterial and insecticidal activity and has found...

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