Antimicrobials

Tiamulin

Tiamulin is a semi-synthetic analogue of pleuromutilin in which the hydroxyacetyl side chain is replaced with a larger diethylaminoethylthioacetyl moiety, providing greater hydrophobicity and an ionisable group for salt formation and greater water...

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Teicoplanin A3-1

Teicoplanin A3-1 is a minor polar analog of a family of lipoglycopeptides produced by Actinoplanes teichomyceticus. Teicoplanins possess potent broad-spectrum antibiotic activity against Gram-positive bacteria, including MRSA and E. faecalis. Teicoplanin...

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Telomycin

Telomycin is a complex, high molecular weight depsipeptide discovered in 1958. The structure was not solved until 1968. Telomycin possesses potent and highly selective activity against Gram positive bacteria in vitro and in vivo when given by...

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TPU-0037A

TPU-0037A (30-Demethyllydicamycin), a close structural analogue of lydicamycin, has been shown to be highly active against MRSA. TPU-0037A is also closely related to BN 4515N which was isolated from a strain of Microtetraspora as a neuritogenic agent...

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TPU-0037C

TPU-0037C (8-Dehydroxy-30-demethyllydicamycin), a close structural analogue of lydicamycin, has been shown to be highly active against MRSA. TPU-0037C is also closely related to BN 4515N which was isolated from a strain of Microtetraspora as a...

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Doripenem Hydrate

Doripenem Hydrate is a β-lactam antibiotic of the carbapenem class, specifically a 1-β-methyl carbapenem.  It is effective against extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae, a microbe resistant to many first...

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Nitazoxanide

Nitazoxanide is a thiazolid drug used primarily in the treatment of Giardia intestinalis infection in humans. In addition to its antiparasitic activity, it as also demonstrated promise against a broad spectrum of gram-postive and gram-negative bacterial...

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Retapamulin

Retapamulin is a semi-synthetic pleuromutilin prepared by reacting pleuromutilin tosylate with tropine-3-thiol to give a more hydrophobic analogue with a tertiary amine. This enables formulation as a stable hydrochloride salt. Retapamulin is a broad...

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Bromothricin

Bromothricin is a directed biosynthetic analogue of chlorothricin, produced by a chlorothricin-producing strain of Streptomyces antibioticus using media supplemented with potassium bromide. The bromide preferentially replaces the chlorine in the benzoate...

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Rugulotrosin A

Rugulotrosin A is a symmetric dimer isolated from an uncharacterised species of Penicillium. Rugulotrosin A displays significant antibacterial activity against a wide range of Gram positive bacteria, but has received no further investigation.Rugulotrosin...

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Azamulin

Azamulin is a semi-synthetic pleuromutilin prepared by sequential reaction of dihydropleuromutilin tosylate with 2-amino-1,2,4-triazole-5-thiol. While azamulin is a broad spectrum antibiotic in the pleuromutilin class, this aspect of its bioprofile has...

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Rolitetracycline

Rolitetracycline, launched in the late 1950s, was the first of the semi-synthetic tetracyclines. Rolitetracycline is formed by a Mannich condensation of formaldehyde and pyrrolidine with tetracycline. Rolitetracycline is a pro-drug of tetracycline, in...

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