TPU-0037C (8-Dehydroxy-30-demethyllydicamycin), a close structural analogue of lydicamycin, has been shown to be highly active against MRSA. TPU-0037C is also closely related to BN 4515N which was...
Doripenem Hydrate is a β-lactam antibiotic of the carbapenem class, specifically a 1-β-methyl carbapenem. It is effective against extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae, a...
Nitazoxanide is a thiazolid drug used primarily in the treatment of Giardia intestinalis infection in humans. In addition to its antiparasitic activity, it as also demonstrated promise against a...
Retapamulin is a semi-synthetic pleuromutilin prepared by reacting pleuromutilin tosylate with tropine-3-thiol to give a more hydrophobic analogue with a tertiary amine. This enables formulation as a...
Bromothricin is a directed biosynthetic analogue of chlorothricin, produced by a chlorothricin-producing strain of Streptomyces antibioticus using media supplemented with potassium bromide. The...
Rugulotrosin A is a symmetric dimer isolated from an uncharacterised species of Penicillium. Rugulotrosin A displays significant antibacterial activity against a wide range of Gram positive bacteria,...
Azamulin is a semi-synthetic pleuromutilin prepared by sequential reaction of dihydropleuromutilin tosylate with 2-amino-1,2,4-triazole-5-thiol. While azamulin is a broad spectrum antibiotic in the...
Rolitetracycline, launched in the late 1950s, was the first of the semi-synthetic tetracyclines. Rolitetracycline is formed by a Mannich condensation of formaldehyde and pyrrolidine with tetracycline...
Saccharocarcin A is an unusual tetronic acid structurally related to kijanimicin, chlorothricin, tetrocarcin and versipelostatin, which has pronounced activity against Gram positive bacteria and...
Saccharocarcin B is an unusual tetronic acid structurally related to kijanimicin, chlorothricin, tetrocarcins and versipelostatin, which has pronounced activity against Gram positive bacteria and...
Pirlimycin is a semi-synthetic lincosamide prepared from clindamycin by hydrolysing the propyl N-methylproline and re-annealing a 4-ethylpipecolic acid. Pirlimycin is more hydrophobic than...
Pseudomonic Acid is a potent antibiotic produced by Pseudomonas fluorescens. Pseudomonic Acid has broad-spectrum activity against Gram-positive bacteria.Pseudomonic Acid is soluble in ethanol,...
