Antimicrobials

L-156602

L-156602 is a cyclic hexapeptide isolated from a strain of Streptomyces by researchers at Merck USA and reported in 1991. L-156602 belongs to the aurantimycin class and, like other members, is active against Gram positive bacteria. L-156602 was foremost...

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Dermcidin

Dermcidin is an antimicrobial peptide (AMP) expressed in human sweat glands and is part of the human body's innate immune defense. Several truncated versions of dermcidin naturally occur in sweat, several of them showing broad-spectrum antibacterial...

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Lydicamycin

Lydicamycin belongs to a novel structural class with highly selective antibiotic activity. Recent research has shown that Lydicamycin and the related metabolites, TPU-0037A and TPU-0037C, are highly active against MRSA. Lydicamycin is also closely...

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Ionomycin

Ionomycin was isolated from Streptomyces conglobatus as a potent Gram positive antibiotic. During isolation, it was recognised that ionomycin exhibits a very high affinity and selectivity for calcium ions, suggesting the metabolite acts as a calcium...

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Indanomycin

Indanomycin is an unusual pyrollic ionophore active against Gram positive bacteria and insects. Interestingly, indanomycin has antihypertensive properties. Indanomycin possesses affinity for both mono- and divalent ions, and has been reported as a growth...

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Nodusmicin

Nodusmicin is a co-metabolite of nargenicin, bearing the core macrocyclic lactone but lacking the pyrrole ester. Like nargenicin, nodusmicin is a potent antibiotic active against both aerobic and anaerobic bacteria. Lack of availability has restricted a...

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Nargenicin

Nargenicin (CP-47,444) is a 10-membered macrocyclic lactone isolated from Nocardia in 1980 as an antibiotic. The macrocyclic lactone is anchored through vicinal carbons to a decalin bearing a pyrrole ester. Nargenicin exhibits potent activity against...

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Micrococcin P1

Micrococcin P1 is a macrocyclic thiopeptide originally isolated from Micrococcus sp. by Su (Oxford) in 1948 and is considered the founding member of the thiopeptide antibiotic family.  It was purified by Heatley and Doery but the producing strain...

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Alpha-lipomycin

α-Lipomycin is an unusual pentaenone tetramic acid first isolated from Streptomyces aureofaciens in 1972. Lipomycin has potent Gram positive antibacterial activity with no activity against fungi, including yeasts. The antibiotic activity is antagonized...

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Alamethicin F50

Alamethicin F50 is a neutral linear peptaibol complex with potent antibiotic activity, containing 20 "amino acids" with acetyl and phenylalaninol termini, produced by Trichoderma sp.. Alamethicin F50 is co-produced with an acidic linear peptaibol complex...

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Aflatoxin G2

Aflatoxin G2 is the minor analogue of the green fluorescent family of bisfuranocoumarin mycotoxins produced by Aspergillus flavus and related species. Aflatoxins are one of the most potent mycotoxins known but are in fact 'pre-toxins', requiring...

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Aflatoxin G1

Aflatoxin G1 is the major analogue of the green fluorescent family of bisfuranocoumarin mycotoxins produced by Aspergillus flavus and related species. Aflatoxins are one of the most potent mycotoxins known but are in fact 'pre-toxins', requiring...

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