Antimicrobials

Pseudomonic Acid

Pseudomonic Acid is a potent antibiotic produced by Pseudomonas fluorescens.  Pseudomonic Acid has broad-spectrum activity against Gram-positive bacteria.Pseudomonic Acid is soluble in ethanol, methanol, DMF and DMSO.  It has limited water...

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Platencin

Platencin is a novel, broad spectrum, Gram-positive antibiotic produced by strains of Streptomyces platensis. Platencin is more potent than its analogue, platensimycin. Platencin shows potent in vivo efficacy without any observed toxicity. Platencin...

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Quinupristin Mesylate

Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogrycin B, pristinamycin IA, streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone. Addition of...

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Platensimycin

Platensimycin is a novel, broad spectrum, Gram-positive antibiotic produced by strains of Streptomyces platensis. Its discovery was heralded by high profile publication and commentary in the scientific and lay press. Platensimycin was discovered by a...

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Pleuromutilin

Pleuromutilin is a diterpene produced by several species of basidomycete, notably the genus Pleurotus, discovered in 1951. Pleuromutilin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross...

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Tildipirosin

Tildipirosin is a semi-synthetic antibiotic derived from a tylosin derivative by iodination and reaction with piperidine. The introduction of a third basic moiety into the tylosin core provides a wider spectrum of antibiotic action than the dibasic...

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Phenelfamycin E

Phenelfamycin E is the major analogue of the phenelfamycin complex produced by several species of Strepyomyces. The phenelfamycins are potent antibiotics with good activity against Gram positive bacteria, notably Clostridium difficile, however...

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Parvodicin

Parvodicin is a family of glycopeptides with potent antibiotic activity, isolated from Actinomadura parvosata. Structurally the parvodicins share a common cyclic peptide core with ristocetin. The analogues within the complex vary in the fatty acid...

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Ostreogrycin A

Ostreogrycin A (virginiamycin M1, streptogramin A) is the major component of the virginiamycin complex. In the 1950s this complex was independently discovered so many times that the literature became highly confusing. Ostreogrycin A is a macrocyclic...

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L-156602

L-156602 is a cyclic hexapeptide isolated from a strain of Streptomyces by researchers at Merck USA and reported in 1991. L-156602 belongs to the aurantimycin class and, like other members, is active against Gram positive bacteria. L-156602 was foremost...

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Dermcidin

Dermcidin is an antimicrobial peptide (AMP) expressed in human sweat glands and is part of the human body's innate immune defense. Several truncated versions of dermcidin naturally occur in sweat, several of them showing broad-spectrum antibacterial...

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Lydicamycin

Lydicamycin belongs to a novel structural class with highly selective antibiotic activity. Recent research has shown that Lydicamycin and the related metabolites, TPU-0037A and TPU-0037C, are highly active against MRSA. Lydicamycin is also closely...

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