Antimicrobials

Chromomycin A3

Chromomycin A3 is the major component of the chromomycin complex of the aureolic acid class, isolated from several Streptomyces species, and first reported in 1960. Chromomycin A3 exhibits a broad biological profile as an antibacterial, antifungal and...

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Collismycin

Collismycin is a rare and unusual antibiotic belonging to the caerulomycin class, containing a core 2,2'-bispyridyl with an oxime substituent, produced by a strain of Streptomyces and discovered by researchers from Kirin, Japan in 1994. Collismycin was...

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Concanamycin A

Concanamycin A is the major analogue of the concanamycin complex produced by Streptomyces sp.. It has been shown to act as a potent and specific vacuolar-ATPase inhibitor. Concanamycin A inhibits the acidification of organelles and blocks cell surface...

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Resistoflavine

Resistoflavine is a rare, boat-shaped, pentacyclic polyketide isolated from several species of Streptomyces, often co-produced with resistomycin. Resistoflavine exhibits weak antibacterial activity against Gram positive and Gram negative bacteria and...

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Natamycin

Natamycin is a natural small molecule.  It is an antifungal polyene macrolide that binds to ergosterol and blocks fungal growth, without changing the permeability of the plasma membrane. It was isolated in 1955 from fermentation broth of...

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Cytochalasin B

Cytochalasin B is one of the most extensively studied members of a family of potent mycotoxins produced by several species of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, giving rise to pronounced morphogenic...

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7-Aminocephalosporanic Acid

7-Aminocephalosporanic Acid (7-ACA) is a key intermediate in the production of a wide variety of semisynthetic Cephalosporin antibiotics.  It is an inhibitor of bacterial (S. aureus) β-lactamase.  It is derived from mild acid...

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Anguinomycin A

Anguinomycin A is a natural polyketide and analog of Leptomycin B, an inhibitor of protein nuclear export.  It is isolated from Streptomyces spp., and displays anti-cancer activity.  Anguinomycins B, C and D are also members of the Leptomycin...

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Sch 38519

Sch 38519 is an isochromanequinone, structurally related to lactoquinomycin. Sch 38519 inhibits thrombin-induced aggregation of human platelets and is active against Gram positive and Gram negative bacteria.Sch 38519 is soluble in ethanol, methanol,...

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Cytochalasin E

Cytochalasin E is one of a family of potent mycotoxins produced by a range of fungi. Despite the common mode of action, there is evidence that individual members display diverse selectivity. Specifically, cytochalasin E acts as an angiogenesis inhibitor...

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Cytochalasin H

Cytochalasin H is one of a family of potent mycotoxins produced by a range of fungi. In vitro, cytochalasin H exhibits antibacterial, antifungal, nematocidal and antitumor activity.Cytochalasin H is soluble in ethanol, methanol, DMF and DMSO...

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Borrelidin

Borrelidin is an unusual nitrile-containing metabolite isolated from Streptomyces. Borrelidin is an important lead for antimalarial discovery, displaying activity against drug-resistant Plasmodia.Borrelidin is soluble in ethanol, methanol, DMF and...

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