WF 3681 was isolated from Chaetomella sp. as a novel inhibitor of aldose reductase by researchers at Fujisawa Co. Japan in 1987, exhibiting an IC50 of 2.5 x 10-7 M. WF 3681 does not significantly...
WEB 2086 (apafant) is a potent and selective platelet activating (PAF) antagonist. WEB 2086 has high affinity for guinea pig peritoneal macrophage PAF receptors, dissociating slowly. WEB 2086 at 10-8...
Turmerone is a non-polar 1,4-dialkylaryl metabolite isolated as a constituent of essential oil from turmeric (Curcuma longa), a plant with medicinal and culinary use. Turmerone has antimicrobial,...
Thaxtomin A is a unique dioxopiperazine containing a 4-nitroindol-3-yl moiety isolated by scientists at Dow Agrisciences from Streptomyces scabies, the causative agent of common scab on new potatoes...
Syringic Acid, the 3,5-dimethyl ether derivative of gallic acid, is a phenolic compound found in fruits and vegetables which is synthesized via the shikimic acid pathway in plants. Syringic Acid has...
Streptomycin, a metabolite of Streptomyces griseus, was first published as an antibiotic active against Gram-positive and Gram-negative bacteria by Schatz, Bugie and Waksman in 1944. Streptomycin was...
1,3-Diphenylurea is an endogenous metabolite of plants present in coconut milk (Cocos nucifera) amonth other sources. In combination with casein hydrolysate, 1,3-diphenylurea promotes transport of...
spiro-Oxanthromicin was first isolated from a soil-derived Streptomyces sp. by Capon in 2014. spiro-Oxanthromicin inhibits mislocalisation of the oncogenic mutant K-Ras from the plasma membrane of...
Securinine is a tetracyclic alkaloid isolated from the roots of Securinega suffruticosa with an unusual structure in which the piperidine ring has a skewed boat form and the diene is not coplanar...
Sartorypyrone D is a meroterpenoid produced by Neosartorya fischeri FO-5897 and isolated by Omura and co-workers at the Kitasato Institute, Japan, in 2015. Sartorypyrone D is a potent inhibitor of...
Rubiginone D2 was isolated from a Streptomyces sp. by Zeeck and co-workers, University of Gottingen, Germany in 2000. Rubiginone D2 is an angucycline, an angular tetracyclic benzanthracene core...
Pyrenophorin, the diketone analogue of pyrenophorol, was first reported as a metabolite of the oat pathogen Pyrenophora avenae showing cytostatic properties. Pyrenophorin is a simple macrocyclic...
