Antibacterials

Phomopsinamine

Phomopsinamine is a potent mycotoxin produced by the fungus, Phomopsis leptostromiformis. Phomopsinamine is formed by hydrolysis of the dicarboxylic acid of phomopsin A. The phomopsins cause lupinosis in livestock fed infected lupins. Phomopsinamine is a...

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Pepstatin A

Pepstatin A, a pentapeptide isolated from Streptomyces sp. is a strong inhibitor of aspartyl proteases such as pepsin, cathepsin D, and renin. Pepstatin is active against HIV-1 and Plasmodium falciparum. HIV-infected H9 cells...

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Pentalenic acid

Pentalenic acid has been isolated from many Streptomyces sp. as a co-metabolite of the sesquiterpenoid antibiotic pentalenolactone and related natural products. Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family...

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Penipurdin A

Penipurdin A was first reported as an orange-red anthraquinone produced by soil-derived Penicillium purpurogenum by Li and co-workers from the Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong, China in 2015...

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Palmarumycin C3

The palmarumycins are fungal metabolites isolated from Coniothyrium and Sphaeropsidales sp. with antifungal, antibacterial, antitumor and herbicidal properties. Palmarumycin C3 is a yellow-green pigment which inhibits Ras farnesyl-protein...

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Pactamycin

Pactamycin (syn: Pactacin) is a unique type of highly-substituted aminocyclitol produced by Streptomyces sp. which is a potent inhibitor of translation in eukaryotes, bacteria and archaea, active against Gram-positive and Gram-negative bacteria. ...

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Oosporein

Oosporein is a purple-red pigment published as a metabolite of Acremonium sp. in 1959. Oosporein has antibacterial, antiviral and antifungal activity. Oosporein is produced by the entomopathogenic fungus Beauveria bassiana after host death, acting to...

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Nikkomycin Z

Nikkomycin Z is a natural product, a nucleoside-type antibiotic isolated from Steptomyces tendae in the mid-1970s. Nikkomycin Z has potent narrow-spectrum activity against some fungi, including Rhizopus cirdinans, Colletrotrichum trifolii and Botrytis...

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Neosartoricin B

Neosartoricin B was produced biosynthetically in 2013 by Tang and colleagues from UCLA USA by selecting the gene cluster for neosartoricin that is homologous to a conserved cluster among dermatophytes of the Trichophyton and Arthroderma genera. When...

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Neosartoricin

Neosartoricin is a carbotricyclic metabolite produced by Aspergillus fumigatus and Neosartorya fischeri following activation of their polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters, reported by Tang and...

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Nanangenine H

The nanangenines are newly discovered drimane sesquiterpenoid metabolites from a hitherto undescribed Australian fungus, Aspergillus nanangensis. Nanangenine H is an acylated drimane which is a putative biosynthetic intermediate of the higher nanagenines...

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Nanangenine G

The nanangenines are newly discovered drimane sesquiterpenoid metabolites from a hitherto undescribed Australian fungus, Aspergillus nanangensis. Nanangenine G is an acylated drimane which is a putative biosynthetic intermediate of the higher...

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