Antibacterials

Nanangenine D

The nanangenines are newly discovered drimane sesquiterpenoid metabolites from a hitherto undescribed Australian fungus, Aspergillus nanangensis. Nanangenine D is a drimane lactone bearing a C8 acyl side chain. Nanangenine D has potent activity against B...

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Nanangenine C

The nanangenines are newly discovered drimane sesquiterpenoid metabolites from a hitherto undescribed Australian fungus, Aspergillus nanangensis. Nanangenine D is a drimane lactone bearing a C6 acyl side chain. Nanangenine D has potent activity against B...

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Nanangenine B

The nanangenines are newly discovered drimane sesquiterpenoid metabolites from a hitherto undescribed Australian fungus, Aspergillus nanangensis. Nanangenine B is a drimane lactone bearing a C6 acyl side chain. Nanangenine C has weak activity against B...

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Monascinol

Monascinol is a yellow-orange pigment isolated from the fungus Monascus purpureus used to produce red yeast ric . Monascinol increases the efficacy of irradiation in PC-3 prostate cancer cells, enhancing DNA damage and endoplasmic reticulum stress...

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Nanangenine A

The nanangenines are newly discovered drimane sesquiterpenoid metabolites from a hitherto undescribed Australian fungus, Aspergillus nanangensis. Nanangenine A is a trihydroxylated drimane lactone which was inactive in assays for antibiotic, cytotoxic,...

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Monascin

Monascin (monascoflavin) is a yellow-orange pigment isolated from the fungus, Monascus purpureus used to produce red yeast rice. The structure of monascin was elucidated in 1960. Monascin has a broad bioprofile, including anti-inflammatory, antioxidant,...

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Mensacarcin

Mensarcarcin is an unusual anthracene metabolite of Streptomyces sp. containing nine stereogenic centres and two epoxy functionalities first isolated by Zeeck and co-workers in the late 1990s. Mensacarcin has broad antitumor activity...

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Malolactomycin C

Malolactomycin C, produced by Streptomyces sp., is the N-demethyl analogue of the malolactomycin family, a 40-membered macrolide. Malolactomycin C has moderate activity against selected fungi, specifically Cladosporium, Botrytis, and Pyricularia. Its...

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Lupanine

Lupanine is a tetracyclic quinolizidine isolated from lupins. Lupanine inhibits the growth of phytopathogenic fungi, reducing the germination of conidia of powdery mildew and the further development to appressoria with an IC50 of 1-5 mmol/L. Lupanine...

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Linearmycin A

Linearmycin A is novel linear polyene antibiotic isolated from mycelial extracts of Streptomyces sp. Linearmycin A and B have similar, long linear structures terminating with amino and carboxylic acid groups. The carboxylic acid terminal of linearmycin A...

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Kynurenic Acid

Kynurenic acid is an endogenous tryptophan metabolite of mammals and a constituent of Ephedra transitoria. Kynurenic acid is an antagonist of N-​methyl-​D-​aspartate (NMDA) and α-​7 nicotinic acetylcholine (α7nACh) receptors and scavenges...

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Indole-3-propionic acid

Indole-3-propionic acid is a tryptophan metabolite long recognised as a plant growth regulator. Indole-3-propionic acid is produced by microbiota in the human gut, including Clostridium sporogenes. Indole-3-propionic acid is a potent antioxidant and free...

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