Antibacterials

Monascin

Monascin (monascoflavin) is a yellow-orange pigment isolated from the fungus, Monascus purpureus used to produce red yeast rice. The structure of monascin was elucidated in 1960. Monascin has a broad bioprofile, including anti-inflammatory, antioxidant,...

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Mensacarcin

Mensarcarcin is an unusual anthracene metabolite of Streptomyces sp. containing nine stereogenic centres and two epoxy functionalities first isolated by Zeeck and co-workers in the late 1990s. Mensacarcin has broad antitumor activity...

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Malolactomycin C

Malolactomycin C, produced by Streptomyces sp., is the N-demethyl analogue of the malolactomycin family, a 40-membered macrolide. Malolactomycin C has moderate activity against selected fungi, specifically Cladosporium, Botrytis, and Pyricularia. Its...

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Lupanine

Lupanine is a tetracyclic quinolizidine isolated from lupins. Lupanine inhibits the growth of phytopathogenic fungi, reducing the germination of conidia of powdery mildew and the further development to appressoria with an IC50 of 1-5 mmol/L. Lupanine...

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Linearmycin A

Linearmycin A is novel linear polyene antibiotic isolated from mycelial extracts of Streptomyces sp. Linearmycin A and B have similar, long linear structures terminating with amino and carboxylic acid groups. The carboxylic acid terminal of linearmycin A...

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Kynurenic Acid

Kynurenic acid is an endogenous tryptophan metabolite of mammals and a constituent of Ephedra transitoria. Kynurenic acid is an antagonist of N-​methyl-​D-​aspartate (NMDA) and α-​7 nicotinic acetylcholine (α7nACh) receptors and scavenges...

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Indole-3-propionic acid

Indole-3-propionic acid is a tryptophan metabolite long recognised as a plant growth regulator. Indole-3-propionic acid is produced by microbiota in the human gut, including Clostridium sporogenes. Indole-3-propionic acid is a potent antioxidant and free...

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Indole-3-carboxylic acid

Indole-3-carboxylic acid is a tryptophan metabolite produced by microbiota in the human gut. Indole-3-carboxylic acid isolated from Streptomyces sp. is active against Gram positive bacteria, yeast and fungi. Indole-3-carboxylic acid induces resistance in...

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Indole-3-carboxaldehyde

Indole-3-carboxaldehyde is an endogenous metabolite of plants and is produced in humans by the metabolism of L-tryptophan in Lactobacillus and other gastrointestinal bacteria. Indole-3-carboxaldehyde is an immunomodulator, acting as an agonist of the...

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Hodgkinsine trimethyl triiodide

The hodgkinsines are indole alkaloids from Hodgkinsonia frutescens (family Rubiaceae) containing three linked tryptamine units. There is not much information on the biological activity of hodgkinsine trimethyliodide due to lack of availability of the...

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Hodgkinsine B

The hodgkinsines are indole alkaloids from Hodgkinsonia frutescens (family Rubiaceae) containing three linked tryptamine units. Hodgkinsine B is the enantiomer of hodgkinsine. There is scant information on the biological activity of hodgkinsine B due to...

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Hodgkinsine

The hodgkinsines are indole alkaloids from Hodgkinsonia frutescens (family Rubiaceae) containing three linked tryptamine units. Hodkinsine was first reported by Ritchie et al (University of Sydney) in 1961. Hodgkinsine shows potent dose-​dependent...

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