Simvastatin acid is the active β-hydroxy acid metabolite of simvastatin formed in vivo. Simvastatin acid is a potent inhibitor of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase, an essential enzyme involved in the in vivo synthesis of cholesterol. Simvastatin acid stimulates bone formation by increasing expression of BMP-2 (bone morphogenic protein-2) in osteoblasts.
| Molecular Formula | C25H40O6 |
| References |
Hoffman WF et al (1986) 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side chain ester derivatives of mevinolin. J. Med.Chem. 29:849 Yoshinari M et al (2007) Controlled release of simvastatin acid using cyclodextrin inclusion system. Dental Materials J. 26:451 |
