Sulfapyridine Sodium is the sodium salt of Sulfapyridine, a first-generation sulfonamide discovered in 1937 by L Whitby (May & Baker Ltd). Compound M&B 693, as it was known, was late superseded by penicillin and other sulfonamides during WWII. Sulfapyridine has antibacterial and anti-inflammatory activity and can be used in immunodeficiency research. Sulfapyridine can be used in an oxygen radical absorbance capacity (ORAC) where it scavenges peroxyl radicals. The prodrug Sulfasalazine is composed of a molecule of Sulfapyridine and a molecule of 5-aminosalicylic acid (5-ASA) linked by an azo bond.
Sulfapyridine Sodium is freely soluble in water.
We also offer:
- Sulfapyridine, USP (S065)
| Mechanism of Action | Sulfapyridine inhibits folic acid synthesis by acting as a competitive inhibitor of dihydropteroate synthetase, an enzyme found in the folic acid synthesis pathway. |
| Microbiology Applications | Sulfapyridine can be used to study inflammmation pathways. It can also be used as an analytical reference standard for food testing and urine testing. |
| Molecular Formula | C11H10N3O2SNa • H2O |
| References |
Henry RJ (1943) The mode of action of Sulfonamides. Bacteriol. Rev. 7(4): 175-262 PMID 16350088 Lowell FC, Spring WC, Finland M (1940) Bactericidal action of Sodium Sulfapyridine and of a glucose-Sulfapyridine solution in human blood. J. Clin. Invest. 19(1):215-218. PMID 16694726 Moreno V, Adnane A, Salghi R, Zougagh M, and Ríos A (2019) Nanostructured hybrid surface enhancement Raman scattering substrate for the rapid determination of Sulfapyridine in milk samples. Talanta. 194:357-362 Paniker U and Levine N (2001) Dapsone and Sulfapyridine. Dermatologic Clinics 19(1):79-86 Shakirova F, Shishov A, Bulatov A (2021) Automated liquid-liquid microextraction and determination of sulfonamides in urine samples based on Schiff bases formation in natural deep eutectic solvent media. Talanta 234:122660 |
