Teicoplanin A2-3 is a major analog of a family of lipoglycopeptides produced by Actinoplanes teichomyceticus. Teicoplanins possess potent broad-spectrum antibiotic activity against Gram-positive bacteria, including MRSA and E. faecalis.
Teicoplanin A2-3 is soluble in ethanol, methanol, DMF and DMSO.
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Molecular Formula | C88H97Cl2N9O33 |
Spectrum | Teicoplanins are bactericidal only for Gram-positive bacteria. They have activity against MRSA and multi-resistant enterococci. |
Microbiology Applications |
Teicoplanin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
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References | Parenti F et al (1978) Teichomycins, new antibiotics from Actinoplanes teichomyceticus nov. sp. J. Antibiotics 31:276 Goldstein BP et al (1994) Teicoplanin. In: Glycopeptide antibiotics. ed. Nagarajan R, Dekker New York. 273 |